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The review focuses on calcium accumulation by secretory organelles. The observation that secretory granules contain variable and often important quantities of calcium (1-200 mM of total calcium) can be interpreted as a maturation index. A progressive loading with calcium would be permitted by a Ca2(+)-transport mechanism on the granular membrane and calcium-binding molecules in the granular core. The saturation of this store by the stimulus-induced calcium transient would permit in mature (calcium-loaded) granules the ionic crisis leading to exocytosis. The inside of secretory organelles being acidic, calcium influx into the granule can be driven by calcium-proton exchange. The calcium-proton exchanger could be a Ca2(+)-ATPase.
G Nicaise, and
K Maggio, and
S Thirion, and
M Horoyan, and
E Keicher
April 1982,
Federation proceedings,
G Nicaise, and
K Maggio, and
S Thirion, and
M Horoyan, and
E Keicher
September 1970,
Acta diabetologica latina,
G Nicaise, and
K Maggio, and
S Thirion, and
M Horoyan, and
E Keicher
January 1995,
Neuroscience,
G Nicaise, and
K Maggio, and
S Thirion, and
M Horoyan, and
E Keicher
January 1992,
Current topics in cellular regulation,
G Nicaise, and
K Maggio, and
S Thirion, and
M Horoyan, and
E Keicher
December 1984,
Journal of hypertension. Supplement : official journal of the International Society of Hypertension,
G Nicaise, and
K Maggio, and
S Thirion, and
M Horoyan, and
E Keicher
December 1986,
The Journal of cell biology,
G Nicaise, and
K Maggio, and
S Thirion, and
M Horoyan, and
E Keicher
May 1989,
Nihon yakurigaku zasshi. Folia pharmacologica Japonica,
G Nicaise, and
K Maggio, and
S Thirion, and
M Horoyan, and
E Keicher
September 1981,
Canadian journal of physiology and pharmacology,
G Nicaise, and
K Maggio, and
S Thirion, and
M Horoyan, and
E Keicher
January 1976,
The Journal of physiology,
G Nicaise, and
K Maggio, and
S Thirion, and
M Horoyan, and
E Keicher
November 1993,
The Journal of experimental biology,
