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We compared 26 HLA-A, B identical sibling kidney-transplant recipients followed for one to 10 years, with 104 HLA-A, B semi-identical kidney recipients from living, related donors to determine clinical differences. Graft-survival rates were significantly better in the HLA identical group at two years (85 per cent identical versus 53 per cent in semi-identical, P less than 0.005); patient-survival rates were high for both (96 per cent in identical and 87 per cent in semi-identical at two years, P less than 0.005). The incidence of complications was similar in HLA identical and semi-identical recipients. Nine of the 26 grafts in HLA identical recipients failed one week to eight years after transplantation. Rejection caused most of the graft failures. Recipients of HLA identical-sibling kidney transplants have a high patient and graft survival, but they also encounter many complications. Immunologic rejection occurs, even with negative mixed lymphocyte culture, suggesting the importance of donor determinants other than the HLAA, B and D other than the HLA-A, B and D.
J S Cheigh, and
J Chami, and
K H Stenzel, and
R R Riggio, and
S Saal, and
J A Mouradian, and
M Fotino, and
W T Stubenbord, and
A L Rubin
September 1985,
The New England journal of medicine,
J S Cheigh, and
J Chami, and
K H Stenzel, and
R R Riggio, and
S Saal, and
J A Mouradian, and
M Fotino, and
W T Stubenbord, and
A L Rubin
June 1990,
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J S Cheigh, and
J Chami, and
K H Stenzel, and
R R Riggio, and
S Saal, and
J A Mouradian, and
M Fotino, and
W T Stubenbord, and
A L Rubin
February 1981,
Human immunology,
J S Cheigh, and
J Chami, and
K H Stenzel, and
R R Riggio, and
S Saal, and
J A Mouradian, and
M Fotino, and
W T Stubenbord, and
A L Rubin
October 1999,
Hematology/oncology clinics of North America,
J S Cheigh, and
J Chami, and
K H Stenzel, and
R R Riggio, and
S Saal, and
J A Mouradian, and
M Fotino, and
W T Stubenbord, and
A L Rubin
September 1979,
Transplantation,
J S Cheigh, and
J Chami, and
K H Stenzel, and
R R Riggio, and
S Saal, and
J A Mouradian, and
M Fotino, and
W T Stubenbord, and
A L Rubin
January 1994,
Bone marrow transplantation,
J S Cheigh, and
J Chami, and
K H Stenzel, and
R R Riggio, and
S Saal, and
J A Mouradian, and
M Fotino, and
W T Stubenbord, and
A L Rubin
September 1998,
[Rinsho ketsueki] The Japanese journal of clinical hematology,
J S Cheigh, and
J Chami, and
K H Stenzel, and
R R Riggio, and
S Saal, and
J A Mouradian, and
M Fotino, and
W T Stubenbord, and
A L Rubin
August 1987,
The Netherlands journal of medicine,
J S Cheigh, and
J Chami, and
K H Stenzel, and
R R Riggio, and
S Saal, and
J A Mouradian, and
M Fotino, and
W T Stubenbord, and
A L Rubin
January 1994,
Nephron,
J S Cheigh, and
J Chami, and
K H Stenzel, and
R R Riggio, and
S Saal, and
J A Mouradian, and
M Fotino, and
W T Stubenbord, and
A L Rubin
October 1989,
Haematologica,
