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The aim of this study was to evaluate the effect of interferon-alpha therapy on serum and liver HBV DNA in 20 patients with chronic hepatitis B and to correlate the presence or absence of HBV DNA with the clinical response. There were 11 responders and all lost HBV DNA from the serum. Ten of the 11 were followed for 36 months following IFN treatment and remained well with absence of HBeAg and HBV DNA from the serum and with normal ALT. Five also lost HBsAg. HBV DNA became undetectable in the liver of nine of 10 of these patients in whom liver tissue was available for study. HBV DNA persisted in the liver of seven of nine nonresponders and was not detected in two in spite of the presence of HBV DNA and HBeAg in the serum of these two patients. We conclude that IFN may induce long remissions in patients with chronic hepatitis B with loss of HBV DNA from the serum and that occasionally HBV DNA may persist in the liver of such patients.
S V Feinman, and
B Berris, and
R Sooknanan, and
B Fernandes, and
S Bojarski
March 2005,
Zhonghua shi yan he lin chuang bing du xue za zhi = Zhonghua shiyan he linchuang bingduxue zazhi = Chinese journal of experimental and clinical virology,
S V Feinman, and
B Berris, and
R Sooknanan, and
B Fernandes, and
S Bojarski
January 2010,
Antiviral therapy,
S V Feinman, and
B Berris, and
R Sooknanan, and
B Fernandes, and
S Bojarski
March 1991,
Gastroenterology,
S V Feinman, and
B Berris, and
R Sooknanan, and
B Fernandes, and
S Bojarski
January 2000,
Medical science monitor : international medical journal of experimental and clinical research,
S V Feinman, and
B Berris, and
R Sooknanan, and
B Fernandes, and
S Bojarski
May 1990,
Journal of hepatology,
S V Feinman, and
B Berris, and
R Sooknanan, and
B Fernandes, and
S Bojarski
April 2002,
Liver,
S V Feinman, and
B Berris, and
R Sooknanan, and
B Fernandes, and
S Bojarski
June 2001,
World journal of gastroenterology,
S V Feinman, and
B Berris, and
R Sooknanan, and
B Fernandes, and
S Bojarski
November 2004,
Heart and vessels,
S V Feinman, and
B Berris, and
R Sooknanan, and
B Fernandes, and
S Bojarski
November 2005,
Di 1 jun yi da xue xue bao = Academic journal of the first medical college of PLA,
S V Feinman, and
B Berris, and
R Sooknanan, and
B Fernandes, and
S Bojarski
May 1993,
The Journal of antimicrobial chemotherapy,
