-transparent.png){kind=logo}
The sensitivity of Saccharomyces cerevisiae to the antibiotic cordycepin (3'-deoxyadenosine) was found to be decreased by the addition of thiamin to the growth medium. A thiamin transport mutant of S. cerevisiae was also found to be resistant to the growth inhibitory effect of cordycepin. Not only the thiamin uptake but also adenosine uptake by this mutant cell was markedly reduced compared to those by the parent yeast cells. This strongly suggested that cordycepin, an analog of adenosine, is virtually taken up by the thiamin transport system of growing yeast cells; thus the drug sensitivity is decreased by the presence of thiamin in the growth medium.
Related Publications
A Iwashima, and
Y Kawasaki, and
K Nosaka, and
H Nishimura
January 1984,
Molecular & general genetics : MGG,
A Iwashima, and
Y Kawasaki, and
K Nosaka, and
H Nishimura
January 1988,
Folia microbiologica,
A Iwashima, and
Y Kawasaki, and
K Nosaka, and
H Nishimura
September 2021,
Sheng wu gong cheng xue bao = Chinese journal of biotechnology,
A Iwashima, and
Y Kawasaki, and
K Nosaka, and
H Nishimura
November 1976,
Journal of bacteriology,
A Iwashima, and
Y Kawasaki, and
K Nosaka, and
H Nishimura
December 2008,
FEBS letters,
A Iwashima, and
Y Kawasaki, and
K Nosaka, and
H Nishimura
January 2000,
Biological & pharmaceutical bulletin,
A Iwashima, and
Y Kawasaki, and
K Nosaka, and
H Nishimura
January 2000,
BioFactors (Oxford, England),
A Iwashima, and
Y Kawasaki, and
K Nosaka, and
H Nishimura
October 1988,
Biochimica et biophysica acta,
A Iwashima, and
Y Kawasaki, and
K Nosaka, and
H Nishimura
October 1988,
Biochimica et biophysica acta,
A Iwashima, and
Y Kawasaki, and
K Nosaka, and
H Nishimura
January 1981,
Experientia,
