-transparent.png){kind=logo}
A phase I, double-blind, single-dose, randomized, two-period crossover study was conducted to investigate the effects of pimobendan on renal function to assess whether renal events were a contra-indication to its administration. Results in eight healthy volunteers indicated no significant adverse events on renal plasma flow, glomerular filtration rate, or laboratory safety screens; side-effects were also found to be minimal. Further studies are indicated to assess whether, in the proposed treatment group, i.e. patients with heart failure (in whom compromised renal function is common), pimobendan similarly elicits no serious adverse renal effects.
Related Publications
P Martin, and
H Tindall, and
P Rice, and
P Jones, and
G Tregunno, and
J A Davies, and
C R Prentice
October 1992,
Zeitschrift fur Kardiologie,
P Martin, and
H Tindall, and
P Rice, and
P Jones, and
G Tregunno, and
J A Davies, and
C R Prentice
May 1989,
Zeitschrift fur Kardiologie,
P Martin, and
H Tindall, and
P Rice, and
P Jones, and
G Tregunno, and
J A Davies, and
C R Prentice
December 1989,
Journal of cardiovascular pharmacology,
P Martin, and
H Tindall, and
P Rice, and
P Jones, and
G Tregunno, and
J A Davies, and
C R Prentice
December 1992,
Clinical nephrology,
P Martin, and
H Tindall, and
P Rice, and
P Jones, and
G Tregunno, and
J A Davies, and
C R Prentice
September 2023,
American journal of veterinary research,
P Martin, and
H Tindall, and
P Rice, and
P Jones, and
G Tregunno, and
J A Davies, and
C R Prentice
January 2013,
Clinical nephrology,
P Martin, and
H Tindall, and
P Rice, and
P Jones, and
G Tregunno, and
J A Davies, and
C R Prentice
January 1988,
Journal of cardiovascular pharmacology,
P Martin, and
H Tindall, and
P Rice, and
P Jones, and
G Tregunno, and
J A Davies, and
C R Prentice
April 1990,
British journal of clinical pharmacology,
P Martin, and
H Tindall, and
P Rice, and
P Jones, and
G Tregunno, and
J A Davies, and
C R Prentice
September 1988,
The American journal of cardiology,
P Martin, and
H Tindall, and
P Rice, and
P Jones, and
G Tregunno, and
J A Davies, and
C R Prentice
January 1996,
Platelets,
