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The study was undertaken to investigate the effect of phospholipase A2 (PLA2) on the viability of isolated pancreatic acinar cells (PACs) and its possible synergy with ethanol. The survival of PACs may be reduced by PLA2 in a dose-dependent manner. In the presence of 0.25 microgram PLA2.(10(6) cells)-1, all cells died within less than 4 h of incubation at 37 degrees C. A quantity of 180 mM ethanol, which alone was not lethal for PACs, increased the rate of cell death induced by PLA2 at a certain concentration of this enzyme. The present results imply that (1) PLA2 is able to damage PACs in the absence of additional substrates, and (2) at an appropriate activity of PLA2, ethanol may amplify the toxic effects of this lytic enzyme and force autodigestion of the pancreas.
G Letko, and
M Siech
May 1989,
International journal of pancreatology : official journal of the International Association of Pancreatology,
G Letko, and
M Siech
May 1998,
Pancreas,
G Letko, and
M Siech
February 1992,
Pathology, research and practice,
G Letko, and
M Siech
January 1989,
Zeitschrift fur experimentelle Chirurgie, Transplantation, und kunstliche Organe : Organ der Sektion Experimentelle Chirurgie der Gesellschaft fur Chirurgie der DDR,
G Letko, and
M Siech
January 1991,
Biochemistry and cell biology = Biochimie et biologie cellulaire,
G Letko, and
M Siech
July 1985,
The American journal of physiology,
G Letko, and
M Siech
December 1982,
European journal of biochemistry,
G Letko, and
M Siech
January 1979,
The Biochemical journal,
G Letko, and
M Siech
January 2000,
Pancreas,
