Biomaterial Database

Depressant agent from walnut hulls. 1961

B A WESTFALL, and R L RUSSELL, and T K AUYONG

Crushed unripe walnut hulls (Juglans nigra), when extracted with ether, yield an extract which sedates or at least depresses the movements of Daphnia magna, leopard frogs, perch, catfish, goldfish, mice, rats, and rabbits. One purified depressant compound, 5-hydroxy-1,4-naphthoquinone (juglone), has been isolated and tested on most of these species.

UI	MeSH Term	Description	Entries
D009285	Naphthoquinones	Naphthalene rings which contain two ketone moieties in any position. They can be substituted in any position except at the ketone groups.	Naphthalenediones,Naphthazarins,Naphthoquinone
D009754	Nuts	Botanically, a type of single-seeded fruit in which the pericarp enclosing the seed is a hard woody shell. In common usage the term is used loosely for any hard, oil-rich kernel. Of those commonly eaten, only hazel, filbert, and chestnut are strictly nuts. Walnuts, pecans, almonds, and coconuts are really drupes. Brazil nuts, pistachios, macadamias, and cashews are really seeds with a hard shell derived from the testa rather than the pericarp.	Nut
D011600	Psychopharmacology	The study of the effects of drugs on mental and behavioral activity.
D003621	Daphnia	A diverse genus of minute freshwater CRUSTACEA, of the suborder CLADOCERA. They are a major food source for both young and adult freshwater fish.	Daphnias
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D051379	Mice	The common name for the genus Mus.	Mice, House,Mus,Mus musculus,Mice, Laboratory,Mouse,Mouse, House,Mouse, Laboratory,Mouse, Swiss,Mus domesticus,Mus musculus domesticus,Swiss Mice,House Mice,House Mouse,Laboratory Mice,Laboratory Mouse,Mice, Swiss,Swiss Mouse,domesticus, Mus musculus
D051381	Rats	The common name for the genus Rattus.	Rattus,Rats, Laboratory,Rats, Norway,Rattus norvegicus,Laboratory Rat,Laboratory Rats,Norway Rat,Norway Rats,Rat,Rat, Laboratory,Rat, Norway,norvegicus, Rattus
D031324	Juglans	A plant genus of the family JUGLANDACEAE that provides the familiar walnut.	Walnut,Black Walnut,English Walnut,Juglans nigra,Juglans regia,Black Walnuts,English Walnuts,Walnut, Black,Walnut, English,Walnuts,Walnuts, Black,Walnuts, English