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A study was made to determine whether the mixed lymphocyte culture test could detect histocompatibility differences between two strains of the Mongolian gerbil, Meriones unguiculatus. A semi-micro mixed lymphocyte culture was developed using 6 X 10(5) stimulating and responding cells per 0.12 ml culture volume at a ratio of 1:1. A culture period of 120 hours was found to be optimal. Although a weak allogeneic response was demonstrated with the Uclp:(MON) strain responding to stimulating cells from the MON/Tum strain, the reverse was not seen. A mixed lymphocyte reaction to xenogeneic (mouse) cells was demonstrated, and response to the mitogen, phytohemagglutinin, was strong. These data and the low stimulation index obtained in allogeneic culture supported the view that histocompatibility differences among different strains of the Mongolian gerbil are weak.
L M Karavodin, and
L R Ash
April 1968,
Laboratory animal care,
L M Karavodin, and
L R Ash
June 1978,
Veterinary medicine, small animal clinician : VM, SAC,
L M Karavodin, and
L R Ash
June 1983,
Experimental eye research,
L M Karavodin, and
L R Ash
September 1974,
The American journal of anatomy,
L M Karavodin, and
L R Ash
February 1980,
Laboratory animal science,
L M Karavodin, and
L R Ash
January 1986,
Physiology & behavior,
L M Karavodin, and
L R Ash
January 1987,
Neuropatologia polska,
L M Karavodin, and
L R Ash
December 1971,
Journal of reproduction and fertility,
L M Karavodin, and
L R Ash
February 1972,
Animal behaviour,
L M Karavodin, and
L R Ash
June 1978,
Laboratory animal science,
