A model for histone-nonhistone control of ontogenesis. 1977

G Csaba

The co-operation of histones and nonhistones in the known models can sufficiently explain the control of processes occurring within the differentiated cells. To give an explanation--on the same basis--for changes during ontogenesis and for manifestation of the development's program, a new model is needed which supposes the existence of a programming as well as a realizing system. At the start, the realizing system becomes repressed by histones. After this, the programming system gives orders for the production of nonhistones. These latter then activate the adequate (definite) operator of the realizing system and direct, simultaneously, a further programming gene for the production of a specific nonhistone needed for the following step of the program. Further on, the model could give an explanation for the manner in which the differentiated features of the cell are conserved during mitosis. One may suppose, in this case, that the new DNA strands become without delay wholly repressed. The phase-specific nonhistones--characterizing the cell's ontogenesis and produced by direction of the programming genes--will then displace the histones from the adequate DNA-sites.

UI MeSH Term Description Entries
D008954 Models, Biological Theoretical representations that simulate the behavior or activity of biological processes or diseases. For disease models in living animals, DISEASE MODELS, ANIMAL is available. Biological models include the use of mathematical equations, computers, and other electronic equipment. Biological Model,Biological Models,Model, Biological,Models, Biologic,Biologic Model,Biologic Models,Model, Biologic
D006657 Histones Small chromosomal proteins (approx 12-20 kD) possessing an open, unfolded structure and attached to the DNA in cell nuclei by ionic linkages. Classification into the various types (designated histone I, histone II, etc.) is based on the relative amounts of arginine and lysine in each. Histone,Histone H1,Histone H1(s),Histone H2a,Histone H2b,Histone H3,Histone H3.3,Histone H4,Histone H5,Histone H7

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