| D008303 |
Malignant Carcinoid Syndrome |
A symptom complex associated with CARCINOID TUMOR and characterized by attacks of severe flushing of the skin, diarrheal watery stools, bronchoconstriction, sudden drops in blood pressure, edema, and ascites. The carcinoid tumors are usually located in the gastrointestinal tract and metastasize to the liver. Symptoms are caused by tumor secretion of serotonin, prostaglandins, and other biologically active substances. Cardiac manifestations constitute CARCINOID HEART DISEASE. (Dorland, 27th ed; Stedman, 25th ed) |
Carcinoid Syndrome, Malignant,Carcinoid Syndromes, Malignant,Malignant Carcinoid Syndromes,Syndrome, Malignant Carcinoid,Syndromes, Malignant Carcinoid |
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| D010336 |
Pathology |
A specialty concerned with the nature and cause of disease as expressed by changes in cellular or tissue structure and function caused by the disease process. |
Pathologies |
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| D002275 |
Carcinoid Heart Disease |
Cardiac manifestation of gastrointestinal CARCINOID TUMOR that metastasizes to the liver. Substances secreted by the tumor cells, including SEROTONIN, promote fibrous plaque formation in ENDOCARDIUM and its underlying layers. These deposits cause distortion of the TRICUSPID VALVE and the PULMONARY VALVE eventually leading to STENOSIS and valve regurgitation. |
Carcinoid Heart Diseases,Heart Disease, Carcinoid,Heart Diseases, Carcinoid |
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| D004699 |
Endocardium |
The innermost layer of the heart, comprised of endothelial cells. |
Endocardiums |
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| D005337 |
Fibrin |
A protein derived from FIBRINOGEN in the presence of THROMBIN, which forms part of the blood clot. |
Antithrombin I |
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| D005853 |
Geriatrics |
The branch of medicine concerned with the physiological and pathological aspects of the aged, including the clinical problems of senescence and senility. |
Gerontology |
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| D006801 |
Humans |
Members of the species Homo sapiens. |
Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man |
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