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The changes in ovarian levels of immunoreactive atrial natriuretic peptide (irANP) and arginine vasopressin (irAVP) were observed during the estrous cycle of rat. We also demonstrated the synthesis of ovarian ANP. In adult 4-day cycling rats, ovarian level of irANP was found to be the highest on proestrus and was to be the lowest on diestrus. Ovarian irANP level inversely correlated with ovarian level of irAVP. On reverse-phase HPLC, two distinct peaks of ovarian irANP, high and low molecular weight forms, existed in the each stage of the estrous cycle. However, no significant changes in plasma and atrial concentrations of ANP were observed during the cycle. The rat ovary contained mRNA coding for ANP. These data showing the synchronized cyclic change of ovarian irANP and irAVP with the estrous cycle suggest that the ovary locally synthesizes ANP and ovarian ANP may play regulatory roles on the follicular fluid dynamics.
S H Kim, and
K W Cho, and
Y H Hwang, and
S H Oh, and
K H Seul, and
G Y Koh, and
S J Kim
January 1989,
American journal of obstetrics and gynecology,
S H Kim, and
K W Cho, and
Y H Hwang, and
S H Oh, and
K H Seul, and
G Y Koh, and
S J Kim
June 1997,
The Journal of endocrinology,
S H Kim, and
K W Cho, and
Y H Hwang, and
S H Oh, and
K H Seul, and
G Y Koh, and
S J Kim
October 1989,
American journal of obstetrics and gynecology,
S H Kim, and
K W Cho, and
Y H Hwang, and
S H Oh, and
K H Seul, and
G Y Koh, and
S J Kim
August 1982,
Steroids,
S H Kim, and
K W Cho, and
Y H Hwang, and
S H Oh, and
K H Seul, and
G Y Koh, and
S J Kim
November 1988,
Endocrinology,
S H Kim, and
K W Cho, and
Y H Hwang, and
S H Oh, and
K H Seul, and
G Y Koh, and
S J Kim
April 1994,
American journal of obstetrics and gynecology,
S H Kim, and
K W Cho, and
Y H Hwang, and
S H Oh, and
K H Seul, and
G Y Koh, and
S J Kim
February 1990,
Biology of reproduction,
S H Kim, and
K W Cho, and
Y H Hwang, and
S H Oh, and
K H Seul, and
G Y Koh, and
S J Kim
January 1990,
Biology of reproduction,
S H Kim, and
K W Cho, and
Y H Hwang, and
S H Oh, and
K H Seul, and
G Y Koh, and
S J Kim
December 1991,
General and comparative endocrinology,
S H Kim, and
K W Cho, and
Y H Hwang, and
S H Oh, and
K H Seul, and
G Y Koh, and
S J Kim
August 1987,
Lancet (London, England),
