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2-METHYL-3-O-HYDROXYMETHYLPHENYL-4(3H)-QUINAZOLINONE, A METABOLITE OF 2-METHYL-3-O-TOLYL-4(3H)-QUINAZOLINONE IN RABBIT. 1963

M AKAGI, and Y OKETANI, and S YAMANE

UI MeSH Term Description Entries
D006993 Hypnotics and Sedatives Drugs used to induce drowsiness or sleep or to reduce psychological excitement or anxiety. Hypnotic,Sedative,Sedative and Hypnotic,Sedatives,Hypnotic Effect,Hypnotic Effects,Hypnotics,Sedative Effect,Sedative Effects,Sedatives and Hypnotics,Effect, Hypnotic,Effect, Sedative,Effects, Hypnotic,Effects, Sedative,Hypnotic and Sedative
D008660 Metabolism The chemical reactions in living organisms by which energy is provided for vital processes and activities and new material is assimilated. Anabolism,Catabolism,Metabolic Concepts,Metabolic Phenomena,Metabolic Processes,Metabolic Phenomenon,Metabolic Process,Metabolism Concepts,Metabolism Phenomena,Process, Metabolic,Processes, Metabolic,Concept, Metabolic,Concept, Metabolism,Concepts, Metabolic,Concepts, Metabolism,Metabolic Concept,Metabolism Concept,Phenomena, Metabolic,Phenomena, Metabolism,Phenomenon, Metabolic
D008702 Methaqualone A quinazoline derivative with hypnotic and sedative properties. It has been withdrawn from the market in many countries because of problems with abuse. (From Martindale, The Extra Pharmacopoeia, 30th ed, p604) Metolquizolone,Ortonal,Methaqualone Hydrochloride,Optimil,Quaalude,Hydrochloride, Methaqualone
D011817 Rabbits A burrowing plant-eating mammal with hind limbs that are longer than its fore limbs. It belongs to the family Leporidae of the order Lagomorpha, and in contrast to hares, possesses 22 instead of 24 pairs of chromosomes. Belgian Hare,New Zealand Rabbit,New Zealand Rabbits,New Zealand White Rabbit,Rabbit,Rabbit, Domestic,Chinchilla Rabbits,NZW Rabbits,New Zealand White Rabbits,Oryctolagus cuniculus,Chinchilla Rabbit,Domestic Rabbit,Domestic Rabbits,Hare, Belgian,NZW Rabbit,Rabbit, Chinchilla,Rabbit, NZW,Rabbit, New Zealand,Rabbits, Chinchilla,Rabbits, Domestic,Rabbits, NZW,Rabbits, New Zealand,Zealand Rabbit, New,Zealand Rabbits, New,cuniculus, Oryctolagus
D012106 Research Critical and exhaustive investigation or experimentation, having for its aim the discovery of new facts and their correct interpretation, the revision of accepted conclusions, theories, or laws in the light of newly discovered facts, or the practical application of such new or revised conclusions, theories, or laws. (Webster, 3d ed) Research Priorities,Laboratory Research,Research Activities,Research and Development,Activities, Research,Activity, Research,Development and Research,Priorities, Research,Priority, Research,Research Activity,Research Priority,Research, Laboratory
D006571 Heterocyclic Compounds Cyclic compounds that include atoms other than carbon in their ring structure. Heterocyclic Compound,Compound, Heterocyclic,Compounds, Heterocyclic
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D014556 Urine Liquid by-product of excretion produced in the kidneys, temporarily stored in the bladder until discharge through the URETHRA.
D052999 Quinazolinones Chemicals with two conjoined aromatic rings incorporating two nitrogen atoms and one of the carbons oxidized with a keto oxygen. Quinazolinedione,Quinazolinone,Quinazolinediones

Related Publications

M AKAGI, and Y OKETANI, and S YAMANE
Metabolic fate of 2-methyl-3-o-tolyl-4(3H)-quinazolinone. I. 2-nitrobenzo-o-toluidide as an urinary metabolite of 2-methyl-3-o-tolyl-4(3H)-quinazolinone in human.
January 1970, Chemical & pharmaceutical bulletin,
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Metabolic fate of 2-methyl-3-o-tolyl-4(3H)-quinazolinone. II. Metabolism of 2-methyl-3-o-tolyl-4(3H)-quinazolinone by rabbits liver.
January 1970, Chemical & pharmaceutical bulletin,
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[Biotransformation of 2-methyl-3-o-tolyl-4-(3H)-quinazolinone (methaqualone)].
December 1970, Die Pharmazie,
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Metabolic fate of 2-methyl-3-o-tolyl-4(3H)-quinazolinone. 3. Metabolism of 2-methyl-3-o-tolyl-4(3H)-quinazolinone-N-oxide in vivo and in vitro.
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[Biotransformation of 2-methyl-3-o-tolyl-4(3H)-quinazolinone (Methaqualone). 3. Identification of 6-hydroxy-2-methyl-3-(3'-hydroxy-2'-methyl-phenyl)-4(3H)-quinazolinone as a renal elimination product of Methaqualone].
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Some central nervous system depressant properties of 2-methyl-3-o-tolyl-4(3H)-quinazolinone(TR-495).
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Gas chromatographic determination of methaqualone, 2-methyl-3-o-tolyl-4(3H)-quinazolinone, at therapeutic levels in human plasma.
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[Metabolism of 6-amino-2-methyl-3-o-tolyl-4(3H)-quinazolinone. Formation of glycolic acid amide as detoxication reaction].
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Anticonvulsant and other pharmacological activities of Tuazolone (2-methyl-3-o-tolyl-4 (3 H) quinazolinone).
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[On the biotransformation of 2-methyl-3-o-tolyl-4(3H)-quinazolinone (Methaqualone). 2. On the structure and synthesis of some renal excretory products].
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