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The effect of a daily supplement with 4 g of n-3 polyunsaturated fatty acids (PUFA) for 9 months to 24 healthy volunteers on neutrophil and monocyte chemotaxis was studied using the under-agarose technique. Autologous serum and n-formyl-methionyl-leucyl-phenylalanine were used as chemoattractants. The effect after 9 months of supplementation with n-3 PUFA was also compared to results after short-term supplementation with n-3 PUFA for 6 weeks. Monocyte chemotaxis was reduced after 9 months of supplementation with n-3 PUFA to the same extent as after 6 weeks supplement. Neutrophil-directed migration towards chemoattractants was reduced after 9 months on fish oil, and this decrease was significantly greater than the decrease obtained after 6 weeks of supplementation. The spontaneous migration of neutrophils was significantly attenuated after 9 months compared to baseline and to 6 weeks. These findings lend support to a role for n-3 PUFA in the management of chronic inflammatory and atherosclerotic vascular diseases.
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J Dyerberg
January 1989,
Journal of internal medicine. Supplement,
E B Schmidt, and
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July 1990,
Clinica chimica acta; international journal of clinical chemistry,
E B Schmidt, and
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J Dyerberg
June 1993,
The New England journal of medicine,
E B Schmidt, and
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April 2022,
JAMA,
E B Schmidt, and
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H H Lervang, and
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April 2022,
JAMA,
E B Schmidt, and
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March 1999,
Mechanisms of ageing and development,
E B Schmidt, and
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J Dyerberg
February 2000,
Internal medicine (Tokyo, Japan),
E B Schmidt, and
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J O Pedersen, and
H H Lervang, and
N Grunnet, and
C Jersild, and
J Dyerberg
January 1988,
The British journal of dermatology,
E B Schmidt, and
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H H Lervang, and
N Grunnet, and
C Jersild, and
J Dyerberg
April 2022,
JAMA,
E B Schmidt, and
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H H Lervang, and
N Grunnet, and
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J Dyerberg
February 1995,
Thrombosis research,
