SPLEEN-COLONY FORMATION IN ANEMIC MICE OF GENOTYPE WW. 1964

E A MCCULLOCH, and L SIMINOVITCH, and J E TILL

The hemopoietic cells from anemic mice of genotype WW are less able by 200-fold to take part in colony formationin the spleen than cells from the normal littermates of genotype ww. The genetic defect shows itself in the colony-forming cells, since cells from normal littermate mice formcolonies in the spleens of unirradiated mice of genotype WW. Use of animals of genotype WVVWT as recipients improves the spleen-colony method by removing bias resulting fromthe death of irradiated recipients.

UI MeSH Term Description Entries
D011830 Radiation Effects The effects of ionizing and nonionizing radiation upon living organisms, organs and tissues, and their constituents, and upon physiologic processes. It includes the effect of irradiation on food, drugs, and chemicals. Effects, Radiation,Effect, Radiation,Radiation Effect
D012106 Research Critical and exhaustive investigation or experimentation, having for its aim the discovery of new facts and their correct interpretation, the revision of accepted conclusions, theories, or laws in the light of newly discovered facts, or the practical application of such new or revised conclusions, theories, or laws. (Webster, 3d ed) Research Priorities,Laboratory Research,Research Activities,Research and Development,Activities, Research,Activity, Research,Development and Research,Priorities, Research,Priority, Research,Research Activity,Research Priority,Research, Laboratory
D003585 Cell Biology The study of the structure, behavior, growth, reproduction, and pathology of cells; and the function and chemistry of cellular components. Cellular Biology,Biologies, Cell,Biologies, Cellular,Biology, Cell,Biology, Cellular,Cell Biologies,Cellular Biologies
D004920 Erythropoiesis The production of red blood cells (ERYTHROCYTES). In humans, erythrocytes are produced by the YOLK SAC in the first trimester; by the liver in the second trimester; by the BONE MARROW in the third trimester and after birth. In normal individuals, the erythrocyte count in the peripheral blood remains relatively constant implying a balance between the rate of erythrocyte production and rate of destruction. Erythropoieses
D005838 Genotype The genetic constitution of the individual, comprising the ALLELES present at each GENETIC LOCUS. Genogroup,Genogroups,Genotypes
D000740 Anemia A reduction in the number of circulating ERYTHROCYTES or in the quantity of HEMOGLOBIN. Anemias
D000748 Anemia, Macrocytic Anemia characterized by larger than normal erythrocytes, increased mean corpuscular volume (MCV) and increased mean corpuscular hemoglobin (MCH). Anemias, Macrocytic,Macrocytic Anemia,Macrocytic Anemias
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D013154 Spleen An encapsulated lymphatic organ through which venous blood filters.
D014181 Transplantation Immunology A general term for the complex phenomena involved in allo- and xenograft rejection by a host and graft vs host reaction. Although the reactions involved in transplantation immunology are primarily thymus-dependent phenomena of cellular immunity, humoral factors also play a part in late rejection. Immunology, Transplantation

Related Publications

E A MCCULLOCH, and L SIMINOVITCH, and J E TILL
May 1959, Bollettino della Societa italiana di biologia sperimentale,
E A MCCULLOCH, and L SIMINOVITCH, and J E TILL
March 1973, Experientia,
E A MCCULLOCH, and L SIMINOVITCH, and J E TILL
January 1976, Bulletin de l'Academie polonaise des sciences. Serie des sciences biologiques,
E A MCCULLOCH, and L SIMINOVITCH, and J E TILL
January 1978, Archivum immunologiae et therapiae experimentalis,
E A MCCULLOCH, and L SIMINOVITCH, and J E TILL
April 1979, Journal of cellular physiology,
E A MCCULLOCH, and L SIMINOVITCH, and J E TILL
November 1967, The Journal of experimental medicine,
E A MCCULLOCH, and L SIMINOVITCH, and J E TILL
July 1983, Experientia,
E A MCCULLOCH, and L SIMINOVITCH, and J E TILL
June 1970, Nihon Ketsueki Gakkai zasshi : journal of Japan Haematological Society,
E A MCCULLOCH, and L SIMINOVITCH, and J E TILL
January 1983, Radiobiologiia,
Copied contents to your clipboard!