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In the isolated perfused spinal cord of the bullfrog, baclofen caused a reduction in the rate of spontaneous discharges in the ventral root at lower concentrations than GABA. The inhibitory effect of baclofen was fully present in a chloride-free medium, whereas that of GABA was markedly reduced. In contrast to GABA, which depolarized the dorsal root, baclofen produced a hyperpolarization in the dorsal root. Moreover, baclofen produced a hyperpolarization in the ventral roots. In the rat, the development of spinal reflex inhibition by baclofen was slow and the effect was long-lasting. Baclofen decreased dorsal root reflexes, suggesting a decreased excitability of presynaptic fibres. Baclofen produced a more pronounced and faster inhibitory effect on monosynaptic reflexes than on polysynaptic reflexes. In the monoamine depleted rat, the effect of baclofen on both types of reflexes was markedly reduced. It appears that catecholamines are involved in the effects produced by baclofen.
H Fukuda, and
Y Kudo, and
H Ono
October 1977,
Nihon yakurigaku zasshi. Folia pharmacologica Japonica,
H Fukuda, and
Y Kudo, and
H Ono
July 1985,
The Analyst,
H Fukuda, and
Y Kudo, and
H Ono
April 1993,
Biochimica et biophysica acta,
H Fukuda, and
Y Kudo, and
H Ono
December 1986,
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.),
H Fukuda, and
Y Kudo, and
H Ono
October 1978,
The Journal of pharmacy and pharmacology,
H Fukuda, and
Y Kudo, and
H Ono
October 1978,
Brain research,
H Fukuda, and
Y Kudo, and
H Ono
January 1981,
Experimental brain research,
H Fukuda, and
Y Kudo, and
H Ono
May 1976,
Experientia,
H Fukuda, and
Y Kudo, and
H Ono
August 1975,
Experimental neurology,
H Fukuda, and
Y Kudo, and
H Ono
July 1976,
The Journal of physiology,
