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The effect of ipratropium bromide, a new anticholinergic drug, on the rate of clearance of secretions from the lung and on airways resistance was investigated in 12 healthy subjects in a double-blind cross-over trial with placebo and a control run without aerosol. Before taking the drug the subjects inhaled uniform 5 micrometer tracer particles of polystyrene in which 99mTc had been unleachably incorporated. The initial depth of deposition and the rate of clearance of the particles were obtained from serial gamma counts made externally to the chest over six hours. The difference between drug, placebo and control runs in the deposition patterns of the tracer particles and their subsequent rates of clearance were not significant. The drug treatment resulted in statistically significant falls in specific airway resistance at 1, 2, 3 and 6 hours (P less than 0.02). There was no objective or subjective evidence of side effects from the drug.
R A Francis, and
M L Thompson, and
D Pavia, and
R B Douglas
November 1986,
The American journal of medicine,
R A Francis, and
M L Thompson, and
D Pavia, and
R B Douglas
August 1982,
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R A Francis, and
M L Thompson, and
D Pavia, and
R B Douglas
August 1979,
Thorax,
R A Francis, and
M L Thompson, and
D Pavia, and
R B Douglas
April 1986,
Thorax,
R A Francis, and
M L Thompson, and
D Pavia, and
R B Douglas
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R A Francis, and
M L Thompson, and
D Pavia, and
R B Douglas
January 2003,
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R A Francis, and
M L Thompson, and
D Pavia, and
R B Douglas
March 1984,
Journal of nuclear medicine : official publication, Society of Nuclear Medicine,
R A Francis, and
M L Thompson, and
D Pavia, and
R B Douglas
December 1984,
Rhinology,
R A Francis, and
M L Thompson, and
D Pavia, and
R B Douglas
November 1984,
Journal of nuclear medicine : official publication, Society of Nuclear Medicine,
R A Francis, and
M L Thompson, and
D Pavia, and
R B Douglas
June 2005,
International journal of sports medicine,
