BIOMAT Database Logo BIOMAT Database Logo

Effect of lipid peroxidation on molecular arrangement of phospholipids in liposomes prepared from egg yolk phosphatidylcholine or total rat brain lipids. A 31P NMR study. 1992

V Misík, and K Ondrias, and P Balgavý
Institute of Experimental Pharmacology, Slovak Academy of Sciences, Bratislava.

Changes in molecular arrangement of membrane phospholipids in the course of lipid autoxidation were studied by means of broad-band 31-P NMR spectroscopy. Multilamellar liposomes prepared from egg yolk phosphatidylcholine (PC) or total lipid extracts from rat brains (TL) were used as models. The initial lamellar arrangement of phospholipids of both types changed as lipid peroxidation proceeded and a narrow isotropic signal appeared in the spectra at 0 ppm, this phenomenon being more prominent for TL than for PC. Probably the isotropic signal represents some nonlamellar structures within the membranes of peroxidized lipids.

UI MeSH Term Description Entries
D008055 Lipids A generic term for fats and lipoids, the alcohol-ether-soluble constituents of protoplasm, which are insoluble in water. They comprise the fats, fatty oils, essential oils, waxes, phospholipids, glycolipids, sulfolipids, aminolipids, chromolipids (lipochromes), and fatty acids. (Grant & Hackh's Chemical Dictionary, 5th ed) Lipid
D008081 Liposomes Artificial, single or multilaminar vesicles (made from lecithins or other lipids) that are used for the delivery of a variety of biological molecules or molecular complexes to cells, for example, drug delivery and gene transfer. They are also used to study membranes and membrane proteins. Niosomes,Transferosomes,Ultradeformable Liposomes,Liposomes, Ultra-deformable,Liposome,Liposome, Ultra-deformable,Liposome, Ultradeformable,Liposomes, Ultra deformable,Liposomes, Ultradeformable,Niosome,Transferosome,Ultra-deformable Liposome,Ultra-deformable Liposomes,Ultradeformable Liposome
D008563 Membrane Lipids Lipids, predominantly phospholipids, cholesterol and small amounts of glycolipids found in membranes including cellular and intracellular membranes. These lipids may be arranged in bilayers in the membranes with integral proteins between the layers and peripheral proteins attached to the outside. Membrane lipids are required for active transport, several enzymatic activities and membrane formation. Cell Membrane Lipid,Cell Membrane Lipids,Membrane Lipid,Lipid, Cell Membrane,Lipid, Membrane,Lipids, Cell Membrane,Lipids, Membrane,Membrane Lipid, Cell,Membrane Lipids, Cell
D009682 Magnetic Resonance Spectroscopy Spectroscopic method of measuring the magnetic moment of elementary particles such as atomic nuclei, protons or electrons. It is employed in clinical applications such as NMR Tomography (MAGNETIC RESONANCE IMAGING). In Vivo NMR Spectroscopy,MR Spectroscopy,Magnetic Resonance,NMR Spectroscopy,NMR Spectroscopy, In Vivo,Nuclear Magnetic Resonance,Spectroscopy, Magnetic Resonance,Spectroscopy, NMR,Spectroscopy, Nuclear Magnetic Resonance,Magnetic Resonance Spectroscopies,Magnetic Resonance, Nuclear,NMR Spectroscopies,Resonance Spectroscopy, Magnetic,Resonance, Magnetic,Resonance, Nuclear Magnetic,Spectroscopies, NMR,Spectroscopy, MR
D010713 Phosphatidylcholines Derivatives of PHOSPHATIDIC ACIDS in which the phosphoric acid is bound in ester linkage to a CHOLINE moiety. Choline Phosphoglycerides,Choline Glycerophospholipids,Phosphatidyl Choline,Phosphatidyl Cholines,Phosphatidylcholine,Choline, Phosphatidyl,Cholines, Phosphatidyl,Glycerophospholipids, Choline,Phosphoglycerides, Choline
D010743 Phospholipids Lipids containing one or more phosphate groups, particularly those derived from either glycerol (phosphoglycerides see GLYCEROPHOSPHOLIPIDS) or sphingosine (SPHINGOLIPIDS). They are polar lipids that are of great importance for the structure and function of cell membranes and are the most abundant of membrane lipids, although not stored in large amounts in the system. Phosphatides,Phospholipid
D001923 Brain Chemistry Changes in the amounts of various chemicals (neurotransmitters, receptors, enzymes, and other metabolites) specific to the area of the central nervous system contained within the head. These are monitored over time, during sensory stimulation, or under different disease states. Chemistry, Brain,Brain Chemistries,Chemistries, Brain
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D015227 Lipid Peroxidation Peroxidase catalyzed oxidation of lipids using hydrogen peroxide as an electron acceptor. Lipid Peroxidations,Peroxidation, Lipid,Peroxidations, Lipid
D051381 Rats The common name for the genus Rattus. Rattus,Rats, Laboratory,Rats, Norway,Rattus norvegicus,Laboratory Rat,Laboratory Rats,Norway Rat,Norway Rats,Rat,Rat, Laboratory,Rat, Norway,norvegicus, Rattus

Related Publications

V Misík, and K Ondrias, and P Balgavý
Effect of cholesterol on egg yolk phosphatidylcholine peroxidation in multilamellar liposomes.
December 2001, Die Pharmazie,
V Misík, and K Ondrias, and P Balgavý
Peroxidation of egg yolk phosphatidylcholine liposomes by hypochlorous acid.
December 1994, Biochimica et biophysica acta,
V Misík, and K Ondrias, and P Balgavý
The effect of stobadine on the copper-induced peroxidation of egg yolk phosphatidylcholine in multilamellar liposomes.
September 2004, General physiology and biophysics,
V Misík, and K Ondrias, and P Balgavý
Effect of kampo medicines on lipid peroxidation of phosphatidylcholine liposomes.
June 1991, Die Pharmazie,
V Misík, and K Ondrias, and P Balgavý
Effect of N-alkyl-N,N,N-trimethylamonium bromides on the auto-peroxidation of egg yolk phosphatidylcholine in liposomes.
February 1992, Biochemistry international,
V Misík, and K Ondrias, and P Balgavý
Effect of liposomes on lipid peroxidation and total phospholipids in rabbit ischemic spinal cord model.
November 1992, Neurochemical research,
V Misík, and K Ondrias, and P Balgavý
Perturbation effect of the diheptanoyl phosphatidylcholine on rat brain total lipid liposomes. An electron paramagnetic resonance spectroscopy study.
September 1992, Chemico-biological interactions,
V Misík, and K Ondrias, and P Balgavý
A 31P-NMR study on multilamellar liposomes formed from the lipids of a thermophilic bacterium.
October 1987, Biochemical and biophysical research communications,
V Misík, and K Ondrias, and P Balgavý
[Cholesterol inhibits peroxidation of egg phosphatidylcholine in multilamellar liposomes].
September 2002, Ceska a Slovenska farmacie : casopis Ceske farmaceuticke spolecnosti a Slovenske farmaceuticke spolecnosti,
V Misík, and K Ondrias, and P Balgavý
Chromatographic retention of drug molecules on immobilised liposomes prepared from egg phospholipids and from chemically pure phospholipids.
February 2001, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences,
Copied contents to your clipboard!