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The effects of antihypertensive treatment with four currently used agents (trichlormethiazide, atenolol, nicardipine, and enalapril) on the arterial baroreceptor reflex control of renal sympathetic nerve activity and heart rate were investigated in 45 conscious spontaneously hypertensive rats and 37 age-matched Wistar-Kyoto rats. Antihypertensive agents were administered for 2 weeks beginning at 8 weeks of age to treat and prevent the development of hypertension. Blood pressure was reduced to a similar level (-13 +/- 3 mm Hg, p < 0.05) by each antihypertensive agent. Blood pressure, heart rate, and renal sympathetic nerve activity were recorded in the conscious state during phenylephrine and nitroglycerin ramp infusion. The gain in the baroreceptor reflex was determined from the maximum slope of logistic function curves. Untreated spontaneously hypertensive rats exhibited decreased sensitivity of reflex control of renal sympathetic nerve activity and heart rate (-1.78 +/- 0.07% of control/mm Hg and -2.16 +/- 0.05 beats per minute/mm Hg, respectively) compared with untreated Wistar-Kyoto rats (-3.62 +/- 0.18% of control/mm Hg, p < 0.01, and -3.46 +/- 0.11 beats per minute/mm Hg, p < 0.05, respectively).(ABSTRACT TRUNCATED AT 250 WORDS)
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H Suzuki, and
M Ryuzaki, and
H Kumagai, and
M Ichikawa, and
M Jimbo, and
Y Matsumura, and
T Saruta
October 1980,
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K Kumagai, and
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M Jimbo, and
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May 1974,
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K Kumagai, and
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January 1976,
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February 1990,
Hypertension (Dallas, Tex. : 1979),
K Kumagai, and
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June 1970,
Anesthesiology,
K Kumagai, and
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April 2006,
Journal of pharmacological sciences,
K Kumagai, and
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February 1984,
Acta physiologica Scandinavica,
K Kumagai, and
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T Saruta
February 1990,
Hypertension (Dallas, Tex. : 1979),
K Kumagai, and
H Suzuki, and
M Ryuzaki, and
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M Ichikawa, and
M Jimbo, and
Y Matsumura, and
T Saruta
January 1980,
Farmakologiia i toksikologiia,
K Kumagai, and
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M Ryuzaki, and
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T Saruta
February 1979,
Biulleten' eksperimental'noi biologii i meditsiny,
