A new method for the transfer of preimplantation stages in mice has been developed by using as recipient the "pregnant empty uterus" obtained by ligature at the utero-oviductal junction. Results obtained with several combinations between Wh, CBAT6T6, C57Bl6 strains varied according to transfer media and strain combination, the best percentage of taking being under the level of those reported by other authors. By using transfer within the RAP strain, taking (controlled at 14 days of pregnancy) was similar to the best results generally obtained by the surgical transfer method. The advantages offered by the transfer method are briefly discussed.