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A method for the measurement of cystathionine and perhydro-1,4-thiazepine-3,5-dicarboxylic acid in the urine of a patient with cystathioninuria has been developed, using column liquid chromatography-mass spectrometry. Cystathionine and perhydro-1,4-thiazepine-3,5-dicarboxylic acid were determined by scanning the [M + H]+ ions of each compound. The recoveries were 80-92.4% for cystathionine and 80-100% for perhydro-1,4-thiazepine-3,5-dicarboxylic acid after ion-exchange treatment. The results agreed well with those obtained using an amino acid analyser. The concentrations found for cystathionine and perhydro-1,4-thiazepine-3,5-dicarboxylic acid were 1.289 +/- 0.099 mg/ml and 0.310 +/- 0.0067 mg/ml, respectively.
K Sugahara, and
J Ohta, and
M Takemura, and
H Kodama
November 1984,
Journal of chromatography,
K Sugahara, and
J Ohta, and
M Takemura, and
H Kodama
January 1995,
Physiological chemistry and physics and medical NMR,
K Sugahara, and
J Ohta, and
M Takemura, and
H Kodama
August 1987,
Proceedings of the National Academy of Sciences of the United States of America,
K Sugahara, and
J Ohta, and
M Takemura, and
H Kodama
October 1998,
Metabolism: clinical and experimental,
K Sugahara, and
J Ohta, and
M Takemura, and
H Kodama
August 2000,
Metabolism: clinical and experimental,
K Sugahara, and
J Ohta, and
M Takemura, and
H Kodama
October 1996,
Metabolism: clinical and experimental,
K Sugahara, and
J Ohta, and
M Takemura, and
H Kodama
January 1995,
Analytical biochemistry,
K Sugahara, and
J Ohta, and
M Takemura, and
H Kodama
January 1990,
Polish journal of pharmacology and pharmacy,
K Sugahara, and
J Ohta, and
M Takemura, and
H Kodama
November 2006,
Biomedical chromatography : BMC,
K Sugahara, and
J Ohta, and
M Takemura, and
H Kodama
July 2011,
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences,
