An autonomously functioning thyroid carcinoma associated with euthyroid Graves' disease. 1992

T Michigishi, and Y Mizukami, and N Shuke, and R Satake, and M Noguchi, and T Aburano, and N Tonami, and K Hisada
Department of Nuclear Medicine, Pathology Section, Kanazawa University Hospital, Japan.

A 39-yr-old man with an autonomously functioning thyroid carcinoma is presented. Only 17 similar cases have been reported in the literature. The patient had unilateral Graves' ophthalmopathy. He was euthyroid as reflected by normal TSH concentration, whereas the results of a T3 suppression test established the presence of autonomous thyroid function. A thyroid scan with (123)I revealed a hot nodule corresponding to the location of a papillary carcinoma and remained substantially unchanged after T3 administration. The hyperfunction of the carcinoma itself was clearly confirmed by the intense concentration of (131)I within the tumor on microautoradiograms. While a hot nodule on radioiodine scan is unlikely to be malignant, the possibility of carcinoma should not be overlooked.

UI MeSH Term Description Entries
D006980 Hyperthyroidism Hypersecretion of THYROID HORMONES from the THYROID GLAND. Elevated levels of thyroid hormones increase BASAL METABOLIC RATE. Hyperthyroid,Primary Hyperthyroidism,Hyperthyroidism, Primary,Hyperthyroids
D007457 Iodine Radioisotopes Unstable isotopes of iodine that decay or disintegrate emitting radiation. I atoms with atomic weights 117-139, except I 127, are radioactive iodine isotopes. Radioisotopes, Iodine
D008297 Male Males
D011877 Radionuclide Imaging The production of an image obtained by cameras that detect the radioactive emissions of an injected radionuclide as it has distributed differentially throughout tissues in the body. The image obtained from a moving detector is called a scan, while the image obtained from a stationary camera device is called a scintiphotograph. Gamma Camera Imaging,Radioisotope Scanning,Scanning, Radioisotope,Scintigraphy,Scintiphotography,Imaging, Gamma Camera,Imaging, Radionuclide
D002291 Carcinoma, Papillary A malignant neoplasm characterized by the formation of numerous, irregular, finger-like projections of fibrous stroma that is covered with a surface layer of neoplastic epithelial cells. (Stedman, 25th ed) Carcinomas, Papillary,Papillary Carcinoma,Papillary Carcinomas
D006111 Graves Disease A common form of hyperthyroidism with a diffuse hyperplastic GOITER. It is an autoimmune disorder that produces antibodies against the THYROID STIMULATING HORMONE RECEPTOR. These autoantibodies activate the TSH receptor, thereby stimulating the THYROID GLAND and hypersecretion of THYROID HORMONES. These autoantibodies can also affect the eyes (GRAVES OPHTHALMOPATHY) and the skin (Graves dermopathy). Basedow's Disease,Exophthalmic Goiter,Goiter, Exophthalmic,Graves' Disease,Basedow Disease,Hyperthyroidism, Autoimmune,Basedows Disease,Disease, Basedow,Disease, Basedow's,Disease, Graves,Disease, Graves',Exophthalmic Goiters,Goiters, Exophthalmic
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000328 Adult A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available. Adults
D013964 Thyroid Neoplasms Tumors or cancer of the THYROID GLAND. Cancer of Thyroid,Thyroid Cancer,Cancer of the Thyroid,Neoplasms, Thyroid,Thyroid Adenoma,Thyroid Carcinoma,Adenoma, Thyroid,Adenomas, Thyroid,Cancer, Thyroid,Cancers, Thyroid,Carcinoma, Thyroid,Carcinomas, Thyroid,Neoplasm, Thyroid,Thyroid Adenomas,Thyroid Cancers,Thyroid Carcinomas,Thyroid Neoplasm

Related Publications

T Michigishi, and Y Mizukami, and N Shuke, and R Satake, and M Noguchi, and T Aburano, and N Tonami, and K Hisada
January 2009, Polskie Archiwum Medycyny Wewnetrznej,
T Michigishi, and Y Mizukami, and N Shuke, and R Satake, and M Noguchi, and T Aburano, and N Tonami, and K Hisada
December 2009, Clinical nuclear medicine,
T Michigishi, and Y Mizukami, and N Shuke, and R Satake, and M Noguchi, and T Aburano, and N Tonami, and K Hisada
February 1997, Journal of nuclear medicine : official publication, Society of Nuclear Medicine,
T Michigishi, and Y Mizukami, and N Shuke, and R Satake, and M Noguchi, and T Aburano, and N Tonami, and K Hisada
November 1995, Clinical nuclear medicine,
T Michigishi, and Y Mizukami, and N Shuke, and R Satake, and M Noguchi, and T Aburano, and N Tonami, and K Hisada
October 1993, Clinical nuclear medicine,
T Michigishi, and Y Mizukami, and N Shuke, and R Satake, and M Noguchi, and T Aburano, and N Tonami, and K Hisada
February 1995, Nuklearmedizin. Nuclear medicine,
T Michigishi, and Y Mizukami, and N Shuke, and R Satake, and M Noguchi, and T Aburano, and N Tonami, and K Hisada
September 1979, Journal of nuclear medicine : official publication, Society of Nuclear Medicine,
T Michigishi, and Y Mizukami, and N Shuke, and R Satake, and M Noguchi, and T Aburano, and N Tonami, and K Hisada
January 1977, The Netherlands journal of medicine,
T Michigishi, and Y Mizukami, and N Shuke, and R Satake, and M Noguchi, and T Aburano, and N Tonami, and K Hisada
March 1980, Journal of nuclear medicine : official publication, Society of Nuclear Medicine,
T Michigishi, and Y Mizukami, and N Shuke, and R Satake, and M Noguchi, and T Aburano, and N Tonami, and K Hisada
January 1987, Gan no rinsho. Japan journal of cancer clinics,
Copied contents to your clipboard!