Biomaterial Database

Detection of human DNA-carcinogen adducts. 1992

F F Kadlubar

National Center for Toxicological Research, US Food and Drug Administration, Jefferson, Arkansas 72079.

UI	MeSH Term	Description	Entries
D007553	Isotope Labeling	Techniques for labeling a substance with a stable or radioactive isotope. It is not used for articles involving labeled substances unless the methods of labeling are substantively discussed. Tracers that may be labeled include chemical substances, cells, or microorganisms.	Isotope Labeling, Stable,Isotope-Coded Affinity Tagging,Isotopically-Coded Affinity Tagging,Affinity Tagging, Isotope-Coded,Affinity Tagging, Isotopically-Coded,Isotope Coded Affinity Tagging,Labeling, Isotope,Labeling, Stable Isotope,Stable Isotope Labeling,Tagging, Isotope-Coded Affinity,Tagging, Isotopically-Coded Affinity
D010761	Phosphorus Radioisotopes	Unstable isotopes of phosphorus that decay or disintegrate emitting radiation. P atoms with atomic weights 28-34 except 31 are radioactive phosphorus isotopes.	Radioisotopes, Phosphorus
D002273	Carcinogens	Substances that increase the risk of NEOPLASMS in humans or animals. Both genotoxic chemicals, which affect DNA directly, and nongenotoxic chemicals, which induce neoplasms by other mechanism, are included.	Carcinogen,Oncogen,Oncogens,Tumor Initiator,Tumor Initiators,Tumor Promoter,Tumor Promoters,Initiator, Tumor,Initiators, Tumor,Promoter, Tumor,Promoters, Tumor
D004247	DNA	A deoxyribonucleotide polymer that is the primary genetic material of all cells. Eukaryotic and prokaryotic organisms normally contain DNA in a double-stranded state, yet several important biological processes transiently involve single-stranded regions. DNA, which consists of a polysugar-phosphate backbone possessing projections of purines (adenine and guanine) and pyrimidines (thymine and cytosine), forms a double helix that is held together by hydrogen bonds between these purines and pyrimidines (adenine to thymine and guanine to cytosine).	DNA, Double-Stranded,Deoxyribonucleic Acid,ds-DNA,DNA, Double Stranded,Double-Stranded DNA,ds DNA
D004249	DNA Damage	Injuries to DNA that introduce deviations from its normal, intact structure and which may, if left unrepaired, result in a MUTATION or a block of DNA REPLICATION. These deviations may be caused by physical or chemical agents and occur by natural or unnatural, introduced circumstances. They include the introduction of illegitimate bases during replication or by deamination or other modification of bases; the loss of a base from the DNA backbone leaving an abasic site; single-strand breaks; double strand breaks; and intrastrand (PYRIMIDINE DIMERS) or interstrand crosslinking. Damage can often be repaired (DNA REPAIR). If the damage is extensive, it can induce APOPTOSIS.	DNA Injury,DNA Lesion,DNA Lesions,Genotoxic Stress,Stress, Genotoxic,Injury, DNA,DNA Injuries

Related Publications

F F Kadlubar

[Immunological detection of carcinogen-DNA adducts].

March 1989, Gan to kagaku ryoho. Cancer & chemotherapy,

F F Kadlubar

Detection of carcinogen-DNA adducts by radiommunoassay.

November 1977, Nature,

F F Kadlubar

Detection of carcinogen-DNA adducts in human cells and antibodies to these adducts in human sera.

January 1987, Progress in experimental tumor research,

F F Kadlubar

Immunological methods for detection of carcinogen-DNA adducts.

January 1984, IARC scientific publications,

F F Kadlubar

Carcinogen-DNA adducts in human breast tissue.

January 1995, Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology,

F F Kadlubar

Carcinogen-DNA adducts in human alveolar macrophages.

January 1992, Respiration; international review of thoracic diseases,

F F Kadlubar

Immunohistochemical detection of carcinogen-DNA adducts and DNA repair in mouse skin.

May 1989, The Journal of investigative dermatology,

F F Kadlubar

Detection of carcinogen-DNA adducts in human fetal tissues by the 32P-postlabeling procedure.

March 1993, Environmental health perspectives,

F F Kadlubar

Antibodies to carcinogen-DNA adducts.

September 1981, Journal of the National Cancer Institute,