Fulminant community acquired infections admitted to an intensive care unit. 1992

S H Khoo, and P Creagh-Barry, and E G Wilkins, and G Pasvol
Department of Infectious Diseases and Tropical Medicine, Northwick Park Hospital, Harrow, UK.

Disease progression, support required, prognostic indicators and survival in hospital and after discharge were studied in 53 patients with community acquired infections who required admission to the intensive care unit from the Department of Infectious Diseases between January, 1985 and August, 1991. The median age was 37 years and over two-thirds of patients were previously fully fit; 38 per cent of patients required intensive care within 6 hours of admission with rapidly progressive disease. Both APACHE II scores and number of organ systems failed were good indicators of prognosis: mortality was 85 per cent in those with three or more organ failures and 86 per cent in those with APACHE II scores of > or = 25. No deaths were observed in those with scores of < 10. Some organ failures (cardiovascular, renal and respiratory) occurred more frequently in those who died. Mechanical ventilation was required by 60 per cent of patients, inotropic drugs by 42 per cent and renal dialysis by 17 per cent. Mortality in hospital was 25 per cent with no further deaths at 6 months to 2 years. As a group these patients were young and previously fit. Deterioration was rapid, necessitating admission to the intensive care unit at short notice. Our results highlight the importance of having intensive care facilities in close proximity to infectious disease units. In contrast to many other groups of patients admitted to the intensive care unit, the overall outlook for patients with community acquired life-threatening infections is good, and long-term monitoring suggests that these patients remain well once recovery has occurred.

UI MeSH Term Description Entries
D007362 Intensive Care Units Hospital units providing continuous surveillance and care to acutely ill patients. ICU Intensive Care Units,Intensive Care Unit,Unit, Intensive Care
D008297 Male Males
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D009102 Multiple Organ Failure A progressive condition usually characterized by combined failure of several organs such as the lungs, liver, kidney, along with some clotting mechanisms, usually postinjury or postoperative. MODS,Multiple Organ Dysfunction Syndrome,Organ Dysfunction Syndrome, Multiple,Organ Failure, Multiple,Failure, Multiple Organ,Multiple Organ Failures
D011379 Prognosis A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations. Prognostic Factor,Prognostic Factors,Factor, Prognostic,Factors, Prognostic,Prognoses
D003141 Communicable Diseases An illness caused by an infectious agent or its toxins that occurs through the direct or indirect transmission of the infectious agent or its products from an infected individual or via an animal, vector or the inanimate environment to a susceptible animal or human host. Infectious Diseases,Communicable Disease,Disease, Communicable,Disease, Infectious,Diseases, Communicable,Diseases, Infectious,Infectious Disease
D005260 Female Females
D006767 Hospitals, District Government-controlled hospitals which represent the major health facility for a designated geographic area. District Hospitals,District Hospital,Hospital, District
D006769 Hospitals, General Large hospitals with a resident medical staff which provides continuous care to maternity, surgical and medical patients. General Hospital,General Hospitals,Hospital, General
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man

Related Publications

S H Khoo, and P Creagh-Barry, and E G Wilkins, and G Pasvol
June 2015, Respiratory medicine,
S H Khoo, and P Creagh-Barry, and E G Wilkins, and G Pasvol
January 2010, Revista portuguesa de pneumologia,
S H Khoo, and P Creagh-Barry, and E G Wilkins, and G Pasvol
June 2006, The European respiratory journal,
S H Khoo, and P Creagh-Barry, and E G Wilkins, and G Pasvol
December 2020, The aging male : the official journal of the International Society for the Study of the Aging Male,
S H Khoo, and P Creagh-Barry, and E G Wilkins, and G Pasvol
May 2017, International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases,
S H Khoo, and P Creagh-Barry, and E G Wilkins, and G Pasvol
December 2023, Annals of intensive care,
S H Khoo, and P Creagh-Barry, and E G Wilkins, and G Pasvol
November 2002, South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde,
S H Khoo, and P Creagh-Barry, and E G Wilkins, and G Pasvol
November 2023, Medicina intensiva,
S H Khoo, and P Creagh-Barry, and E G Wilkins, and G Pasvol
July 2012, Journal of hepatology,
S H Khoo, and P Creagh-Barry, and E G Wilkins, and G Pasvol
December 2009, Veterinary clinical pathology,
Copied contents to your clipboard!