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A novel method for the estimation of fibrinolytic activity is proposed. In this method, a fibrin clot suspension is used as a substrate (fibrin is known to be a physiological substrate of plasmin). The fibrin clot suspension was prepared by homogenization of human fibrin clots. With this method, we found that free fatty acids inhibited the plasmin activity, and long-chain, unsaturated free fatty acids had a particularly strong inhibitory action on plasmin. As regards the mechanism of the inhibitory action, free fatty acids may not inhibit complex formation between plasmin and fibirin, but may make it impossible for plasmin to act on fibrin due to deformation of the surface of the fibrin clot.
T Muraoka, and
H Okuda
November 1986,
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T Muraoka, and
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October 1967,
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T Muraoka, and
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T Muraoka, and
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T Muraoka, and
H Okuda
July 1979,
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T Muraoka, and
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T Muraoka, and
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T Muraoka, and
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T Muraoka, and
H Okuda
February 1987,
Journal of the National Cancer Institute,
