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Distinct decrease in content of prostaglandins PGE, PGF2 alpha and 6-keto-PGF1 alpha was detected in biopsy material, using radioimmunoassay, from gastric mucosal membrane of patients with liver tissue cirrhosis complicated and not complicated by ulcerous disease of stomach or duodenum which correlated with a decrease in secretion of gastric juice (basal and histamine-stimulated secretion). These data suggest considerable impairments of endogenous biosynthesis of prostaglandins in gastric mucosal membrane under conditions of liver tissue cirrhosis, which are of importance in development of ulcerous disease in these patients.
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