The properdin system and immunity. X. Characterization of partially purified human properdin.
1959
I H LEPOW, and
L PILLEMER, and
M D SCHOENBERG, and
E W TODD, and
R J WEDGWOOD
UI
MeSH Term
Description
Entries
D011414
Properdin
A 53-kDa protein that is a positive regulator of the alternate pathway of complement activation (COMPLEMENT ACTIVATION PATHWAY, ALTERNATIVE). It stabilizes the ALTERNATIVE PATHWAY C3 CONVERTASE (C3bBb) and protects it from rapid inactivation, thus facilitating the cascade of COMPLEMENT ACTIVATION and the formation of MEMBRANE ATTACK COMPLEX. Individuals with mutation in the PFC gene exhibit properdin deficiency and have a high susceptibility to infections.
Complement Factor P,Factor P, Complement
D006801
Humans
Members of the species Homo sapiens.
Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
Related Publications
I H LEPOW, and
L PILLEMER, and
M D SCHOENBERG, and
E W TODD, and
R J WEDGWOOD