-transparent.png){kind=logo}
The effects of several inflammatory mediators on the patency of the Eustachian tube were evaluated in 15 mongrel dogs. Histamine, leukotriene C4(LTC4) and D4(LTD4), and platelet activating factor (PAF) were perfused through the Eustachian tube of anesthetized dogs at concentrations detected in human middle ear effusion of patients with otitis media. The patency of the Eustachian tube was then evaluated by perfusion pressure and opening pressure. Histamine at concentrations of more than 10(-5) M caused increased tubal resistance and opening pressure rapidly. LTC4 and LTD4 caused a rapid increase of tubal resistance and opening pressure at far lower concentrations, i.e. 10(-12) M. Doses of PAF over 10(-9) M may cause an increase in the opening pressure. These results indicate that various inflammatory mediators are capable of affecting the Eustachian tube function.
T Minami, and
N Kubo, and
K Tomoda, and
T Kumazawa
February 1978,
Postgraduate medicine,
T Minami, and
N Kubo, and
K Tomoda, and
T Kumazawa
December 1976,
British medical journal,
T Minami, and
N Kubo, and
K Tomoda, and
T Kumazawa
December 1974,
Annales d'oto-laryngologie et de chirurgie cervico faciale : bulletin de la Societe d'oto-laryngologie des hopitaux de Paris,
T Minami, and
N Kubo, and
K Tomoda, and
T Kumazawa
February 1973,
Meditsinskaia radiologiia,
T Minami, and
N Kubo, and
K Tomoda, and
T Kumazawa
May 1973,
Acta oto-laryngologica,
T Minami, and
N Kubo, and
K Tomoda, and
T Kumazawa
February 1964,
The Laryngoscope,
T Minami, and
N Kubo, and
K Tomoda, and
T Kumazawa
April 1957,
The Laryngoscope,
T Minami, and
N Kubo, and
K Tomoda, and
T Kumazawa
November 1977,
The Journal of speech and hearing disorders,
T Minami, and
N Kubo, and
K Tomoda, and
T Kumazawa
January 1957,
Transactions of the American Laryngological, Rhinological and Otological Society, Inc,
T Minami, and
N Kubo, and
K Tomoda, and
T Kumazawa
June 1987,
The Laryngoscope,
