-transparent.png){kind=logo}
According to drug combination principle 26 substituted benzaldehyde/cinnamicaldehyde semicarbazones were synthesized. Twelve of which were not found in literature. The structures of the title compounds were confirmed by elemental and IR, UV, 1HNMR and MS analyses. Thirteen compounds were screened in vivo against Ehrlich ascites tumor cells. Four compounds (VIIf, VIIg, VIIh, VIIm) showed strong antitumor activity. The percent increase in life span were between 46.1%-91.1%. 3-Methoxy-4-hydroxy and 3-methoxy-4-acetyloxy-cinnamicaldehyde selenosemicarbazones showed stronger activity and less toxicity with increase of life span of 76.5% (300 mg/kg) and 91.1% (60 mg/kg), respectively. They were worthy to be studied further.
M Liu, and
P L Xu, and
Z J Wang
September 1988,
Hua xi yi ke da xue xue bao = Journal of West China University of Medical Sciences = Huaxi yike daxue xuebao,
M Liu, and
P L Xu, and
Z J Wang
January 1956,
Antibiotics & chemotherapy (Northfield, Ill.),
M Liu, and
P L Xu, and
Z J Wang
January 1980,
Cancer treatment reports,
M Liu, and
P L Xu, and
Z J Wang
December 1997,
Archiv der Pharmazie,
M Liu, and
P L Xu, and
Z J Wang
May 1985,
Cancer treatment reports,
M Liu, and
P L Xu, and
Z J Wang
September 2009,
European journal of medicinal chemistry,
M Liu, and
P L Xu, and
Z J Wang
February 2004,
Bioorganic & medicinal chemistry letters,
M Liu, and
P L Xu, and
Z J Wang
June 2014,
Archiv der Pharmazie,
M Liu, and
P L Xu, and
Z J Wang
May 1987,
Journal of medicinal chemistry,
M Liu, and
P L Xu, and
Z J Wang
January 1975,
Farmatsevtychnyi zhurnal,
