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Congenital idiopathic growth hormone deficiency associated with prenatal and early postnatal growth failure. The International Board of the Kabi Pharmacia International Growth Study. 1992
P D Gluckman, and
A J Gunn, and
A Wray, and
W S Cutfield, and
P G Chatelain, and
O Guilbaud, and
G R Ambler, and
P Wilton, and
K Albertsson-Wikland
Department of Paediatrics, University of Auckland, New Zealand.
To assess the role of growth hormone in fetal and infant growth, we analyzed the pretreatment data on 52 patients with a diagnosis of congenital growth hormone deficiency before 2 years of age, obtained from the Kabi Pharmacia International Growth Study. These infants had reduced birth-length standard deviation scores, an excess of birth weight relative to length, and progressive growth failure. We conclude that congenital growth hormone deficiency may cause impaired growth in utero and early infancy, and that growth hormone plays an important role in perinatal and infantile growth.
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