-transparent.png){kind=logo}
Using a subtraction cloning approach we had previously isolated a series of murine cDNA clones representing the genes predominantly expressed in the embryonic brain and down-regulated during development. We now report that one of these cDNA clones encodes a novel type of GTP-binding protein. The predicted protein of 40.5 kD, named DRG, contains five structural motifs characteristic of the GTP-binding proteins. Consistently, bacterially expressed and cellular DRG proteins are capable of binding GTP in vitro. Sequences closely related to the DRG protein are found in other species including Drosophila and Halobacterium. Based on these observations, we propose that DRG represents an evolutionarily conserved novel class of GTP-binding protein which may play an important role in cell physiology.
T Sazuka, and
Y Tomooka, and
Y Ikawa, and
M Noda, and
S Kumar
November 2021,
Biochemical and biophysical research communications,
T Sazuka, and
Y Tomooka, and
Y Ikawa, and
M Noda, and
S Kumar
August 2017,
Scientific reports,
T Sazuka, and
Y Tomooka, and
Y Ikawa, and
M Noda, and
S Kumar
April 2013,
American journal of physiology. Endocrinology and metabolism,
T Sazuka, and
Y Tomooka, and
Y Ikawa, and
M Noda, and
S Kumar
June 1996,
Oncogene,
T Sazuka, and
Y Tomooka, and
Y Ikawa, and
M Noda, and
S Kumar
January 2016,
Molecular biology of the cell,
T Sazuka, and
Y Tomooka, and
Y Ikawa, and
M Noda, and
S Kumar
August 2019,
The Journal of cell biology,
T Sazuka, and
Y Tomooka, and
Y Ikawa, and
M Noda, and
S Kumar
December 2007,
Plant molecular biology,
T Sazuka, and
Y Tomooka, and
Y Ikawa, and
M Noda, and
S Kumar
March 1992,
The Journal of biological chemistry,
T Sazuka, and
Y Tomooka, and
Y Ikawa, and
M Noda, and
S Kumar
November 2017,
Biochemical and biophysical research communications,
T Sazuka, and
Y Tomooka, and
Y Ikawa, and
M Noda, and
S Kumar
February 2014,
Clinical immunology (Orlando, Fla.),
