BIOMAT Database Logo BIOMAT Database Logo

Cerebellar LTD and learning-dependent timing of conditioned eyelid responses. 2003

S K E Koekkoek, and H C Hulscher, and B R Dortland, and R A Hensbroek, and Y Elgersma, and T J H Ruigrok, and C I De Zeeuw
Department of Neuroscience, Erasmus MC, 3000 DR Rotterdam, Netherlands.

Mammals can be trained to make a conditioned movement at a precise time, which is correlated to the interval between the conditioned stimulus and unconditioned stimulus during the learning. This learning-dependent timing has been shown to depend on an intact cerebellar cortex, but which cellular process is responsible for this form of learning remains to be demonstrated. Here, we show that protein kinase C-dependent long-term depression in Purkinje cells is necessary for learning-dependent timing of Pavlovian-conditioned eyeblink responses.

UI MeSH Term Description Entries
D007858 Learning Relatively permanent change in behavior that is the result of past experience or practice. The concept includes the acquisition of knowledge. Phenomenography
D008810 Mice, Inbred C57BL One of the first INBRED MOUSE STRAINS to be sequenced. This strain is commonly used as genetic background for transgenic mouse models. Refractory to many tumors, this strain is also preferred model for studying role of genetic variations in development of diseases. Mice, C57BL,Mouse, C57BL,Mouse, Inbred C57BL,C57BL Mice,C57BL Mice, Inbred,C57BL Mouse,C57BL Mouse, Inbred,Inbred C57BL Mice,Inbred C57BL Mouse
D008822 Mice, Transgenic Laboratory mice that have been produced from a genetically manipulated EGG or EMBRYO, MAMMALIAN. Transgenic Mice,Founder Mice, Transgenic,Mouse, Founder, Transgenic,Mouse, Transgenic,Mice, Transgenic Founder,Transgenic Founder Mice,Transgenic Mouse
D009154 Mutation Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations. Mutations
D011493 Protein Kinase C An serine-threonine protein kinase that requires the presence of physiological concentrations of CALCIUM and membrane PHOSPHOLIPIDS. The additional presence of DIACYLGLYCEROLS markedly increases its sensitivity to both calcium and phospholipids. The sensitivity of the enzyme can also be increased by PHORBOL ESTERS and it is believed that protein kinase C is the receptor protein of tumor-promoting phorbol esters. Calcium Phospholipid-Dependent Protein Kinase,Calcium-Activated Phospholipid-Dependent Kinase,PKC Serine-Threonine Kinase,Phospholipid-Sensitive Calcium-Dependent Protein Kinase,Protein Kinase M,Calcium Activated Phospholipid Dependent Kinase,Calcium Phospholipid Dependent Protein Kinase,PKC Serine Threonine Kinase,Phospholipid Sensitive Calcium Dependent Protein Kinase,Phospholipid-Dependent Kinase, Calcium-Activated,Serine-Threonine Kinase, PKC
D011689 Purkinje Cells The output neurons of the cerebellar cortex. Purkinje Cell,Purkinje Neuron,Purkyne Cell,Cell, Purkinje,Cell, Purkyne,Cells, Purkinje,Cells, Purkyne,Neuron, Purkinje,Neurons, Purkinje,Purkinje Neurons,Purkyne Cells
D001767 Blinking Brief closing of the eyelids by involuntary normal periodic closing, as a protective measure, or by voluntary action. Orbicularis Oculi Reflex,Reflex, Blink,Reflex, Corneal,Reflex, Orbicularis Oculi,Winking,Blink Reflexes,Corneal Reflexes,Orbicularis Oculi Reflexes,Blink Reflex,Reflexes, Blink,Reflexes, Orbicularis Oculi
D002531 Cerebellum The part of brain that lies behind the BRAIN STEM in the posterior base of skull (CRANIAL FOSSA, POSTERIOR). It is also known as the "little brain" with convolutions similar to those of CEREBRAL CORTEX, inner white matter, and deep cerebellar nuclei. Its function is to coordinate voluntary movements, maintain balance, and learn motor skills. Cerebella,Corpus Cerebelli,Parencephalon,Cerebellums,Parencephalons
D003215 Conditioning, Eyelid Reflex closure of the eyelid occurring as a result of classical conditioning. Eyelid Conditioning,Conditionings, Eyelid,Eyelid Conditionings
D004597 Electroshock Induction of a stress reaction in experimental subjects by means of an electrical shock; applies to either convulsive or non-convulsive states. Electroconvulsive Shock,Electroconvulsive Shocks,Electroshocks,Shock, Electroconvulsive,Shocks, Electroconvulsive

Related Publications

S K E Koekkoek, and H C Hulscher, and B R Dortland, and R A Hensbroek, and Y Elgersma, and T J H Ruigrok, and C I De Zeeuw
Comment on "Cerebellar LTD and learning-dependent timing of conditioned eyelid responses".
April 2004, Science (New York, N.Y.),
S K E Koekkoek, and H C Hulscher, and B R Dortland, and R A Hensbroek, and Y Elgersma, and T J H Ruigrok, and C I De Zeeuw
Cerebellar cortex lesions disrupt learning-dependent timing of conditioned eyelid responses.
April 1993, The Journal of neuroscience : the official journal of the Society for Neuroscience,
S K E Koekkoek, and H C Hulscher, and B R Dortland, and R A Hensbroek, and Y Elgersma, and T J H Ruigrok, and C I De Zeeuw
Cerebellar cortex contributions to the expression and timing of conditioned eyelid responses.
April 2010, Journal of neurophysiology,
S K E Koekkoek, and H C Hulscher, and B R Dortland, and R A Hensbroek, and Y Elgersma, and T J H Ruigrok, and C I De Zeeuw
Pharmacological analysis of cerebellar contributions to the timing and expression of conditioned eyelid responses.
January 1998, Neuropharmacology,
S K E Koekkoek, and H C Hulscher, and B R Dortland, and R A Hensbroek, and Y Elgersma, and T J H Ruigrok, and C I De Zeeuw
Relating cerebellar purkinje cell activity to the timing and amplitude of conditioned eyelid responses.
May 2015, The Journal of neuroscience : the official journal of the Society for Neuroscience,
S K E Koekkoek, and H C Hulscher, and B R Dortland, and R A Hensbroek, and Y Elgersma, and T J H Ruigrok, and C I De Zeeuw
Cerebellar cortex lesions prevent acquisition of conditioned eyelid responses.
December 1999, The Journal of neuroscience : the official journal of the Society for Neuroscience,
S K E Koekkoek, and H C Hulscher, and B R Dortland, and R A Hensbroek, and Y Elgersma, and T J H Ruigrok, and C I De Zeeuw
Timing correlations between cerebellar interpositus neuronal firing and classically conditioned eyelid responses in wild-type and Lurcher mice.
July 2018, Scientific reports,
S K E Koekkoek, and H C Hulscher, and B R Dortland, and R A Hensbroek, and Y Elgersma, and T J H Ruigrok, and C I De Zeeuw
Learning-dependent timing of Pavlovian eyelid responses: differential conditioning using multiple interstimulus intervals.
August 1992, Behavioral neuroscience,
S K E Koekkoek, and H C Hulscher, and B R Dortland, and R A Hensbroek, and Y Elgersma, and T J H Ruigrok, and C I De Zeeuw
Temporal discrimination in the cerebellar cortex during conditioned eyelid responses.
July 1998, Experimental brain research,
S K E Koekkoek, and H C Hulscher, and B R Dortland, and R A Hensbroek, and Y Elgersma, and T J H Ruigrok, and C I De Zeeuw
Bilateral cerebellar lesions disrupt conditioned eyelid responses in unrestrained rats.
August 1988, Behavioral neuroscience,
Copied contents to your clipboard!