Biomaterial Database

[Guinea pig model of basilar artery thrombosis induced by ferric chloride]. 2003

Zhiqiang Luo, and Weijia Kong, and Xianfeng Zhang, and Hua Peng

Department of Otolaryngology, Second Affiliated Hospital of Nanhua University, Hengyang 421001.

OBJECTIVE The present work was undertaken to establish an animal model of basilar arterial thrombosis. METHODS The bilateral carotid arterial of guinea pigs were ligated and 40% ferric chloride solution was applied to basilar artery topically. The blood flow of cochlea(CBF) was measured continuously with laser doppler flow-meter. The mean arterial pressure (MABP) was recorded simultaneously. The data was analysed by t-test. RESULTS After the administration of 40% FeCl3 to basilar artery, The CBF began decrease significantly from 5 to 10 min, and declined more great along with the prolongation of FeCl3 effect. The CBF reached to (64.5 +/- 4.2)% of the base level at 50 min after FeCl3 exposure. A total average decrease of CBF was (81.3 +/- 12.0)% of the base level throughout the experiment period. The MABP had no significant change. CONCLUSIONS The topical application of 40% FeCl3 solution can offer an ideal model of basilar artery thrombosis.

UI	MeSH Term	Description	Entries
D008297	Male		Males
D008833	Microcirculation	The circulation of the BLOOD through the MICROVASCULAR NETWORK.	Microvascular Blood Flow,Microvascular Circulation,Blood Flow, Microvascular,Circulation, Microvascular,Flow, Microvascular Blood,Microvascular Blood Flows,Microvascular Circulations
D002712	Chlorides	Inorganic compounds derived from hydrochloric acid that contain the Cl- ion.	Chloride,Chloride Ion Level,Ion Level, Chloride,Level, Chloride Ion
D003051	Cochlea	The part of the inner ear (LABYRINTH) that is concerned with hearing. It forms the anterior part of the labyrinth, as a snail-like structure that is situated almost horizontally anterior to the VESTIBULAR LABYRINTH.	Cochleas
D004195	Disease Models, Animal	Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.	Animal Disease Model,Animal Disease Models,Disease Model, Animal
D005290	Ferric Compounds	Inorganic or organic compounds containing trivalent iron.	Compounds, Ferric
D006168	Guinea Pigs	A common name used for the genus Cavia. The most common species is Cavia porcellus which is the domesticated guinea pig used for pets and biomedical research.	Cavia,Cavia porcellus,Guinea Pig,Pig, Guinea,Pigs, Guinea
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D001488	Basilar Artery	The artery formed by the union of the right and left vertebral arteries; it runs from the lower to the upper border of the pons, where it bifurcates into the two posterior cerebral arteries.	Arteries, Basilar,Artery, Basilar,Basilar Arteries
D020767	Intracranial Thrombosis	Formation or presence of a blood clot (THROMBUS) in a blood vessel within the SKULL. Intracranial thrombosis can lead to thrombotic occlusions and BRAIN INFARCTION. The majority of the thrombotic occlusions are associated with ATHEROSCLEROSIS.	Brain Thrombosis,Cerebral Thrombosis,Thrombosis, Brain,Thrombosis, Intracranial,Brain Thrombus,Cerebral Thrombus,Thrombus, Intracranial,Brain Thromboses,Cerebral Thromboses,Intracranial Thromboses,Intracranial Thrombus,Thromboses, Brain,Thromboses, Cerebral,Thromboses, Intracranial,Thrombosis, Cerebral,Thrombus, Brain,Thrombus, Cerebral