Five different glucose-6-phophate [correction phosphate]dehydrogenase (G6PD) variants found among 11 G6PD-deficient persons in Flores Island, Indonesia. 2003

Hiroyuki Matsuoka, and Meiji Arai, and Shigeto Yoshida, and Indah Setyawati Tantular, and Suhintam Pusarawati, and Henyo Kerong, and Fumihiko Kawamoto
Department of Medical Zoology, Jichi Medical School, 3311-1 Yakushiji, Minami-kawachi, Tochigi 329-0498, Japan. hiroyuki@jichi.ac.jp.

We conducted a survey for malaria diagnosis and treatment in four primary schools in Flores Island, one of the Indonesian Islands with an area of 17000 km(2) and a population of 1.8 million. Of those examined, 24.4% were diagnosed as having malaria (90/363) and administered medicine immediately. A glucose-6-phosphate dehydrogenase (G6PD) test was performed at the same time, and 16 persons (4.4%) were diagnosed as G6PD deficient. Eleven persons consented to analysis of the G6PD genome. We analyzed these subjects and found one case of G6PD Vanua Lava (383T>C), five cases of G6PD Coimbra (592C>T), one case of G6PD Viangchan (871G>A), one case of G6PD Chatham (1003G>A), and three cases of G6PD Kaiping (1388G>A). These were unexpected findings because five different G6PD variants were found in such a small population. This suggests that people of Flores Island are derived from various ancestries.

UI MeSH Term Description Entries
D007214 Indonesia A republic stretching from the Indian Ocean east to New Guinea, comprising six main islands: Java, Sumatra, Bali, Kalimantan (the Indonesian portion of the island of Borneo), Sulawesi (formerly known as the Celebes) and Irian Jaya (the western part of New Guinea). Its capital is Djakarta. The ethnic groups living there are largely Chinese, Arab, Eurasian, Indian, and Pakistani; 85% of the peoples are of the Islamic faith. Celebes,Indonesian New Guinea,Irian Jaya,Java,Madoera,Netherlands East Indies,New Guinea, Indonesian,New Guinea, West,Sulawesi,Sumatra,Timor,West Irian,Bali,East Indies,Madura,Malay Archipelago
D008288 Malaria A protozoan disease caused in humans by four species of the PLASMODIUM genus: PLASMODIUM FALCIPARUM; PLASMODIUM VIVAX; PLASMODIUM OVALE; and PLASMODIUM MALARIAE; and transmitted by the bite of an infected female mosquito of the genus ANOPHELES. Malaria is endemic in parts of Asia, Africa, Central and South America, Oceania, and certain Caribbean islands. It is characterized by extreme exhaustion associated with paroxysms of high FEVER; SWEATING; shaking CHILLS; and ANEMIA. Malaria in ANIMALS is caused by other species of plasmodia. Marsh Fever,Plasmodium Infections,Remittent Fever,Infections, Plasmodium,Paludism,Fever, Marsh,Fever, Remittent,Infection, Plasmodium,Plasmodium Infection
D005954 Glucosephosphate Dehydrogenase Glucose-6-Phosphate Dehydrogenase,Dehydrogenase, Glucose-6-Phosphate,Dehydrogenase, Glucosephosphate,Glucose 6 Phosphate Dehydrogenase
D005955 Glucosephosphate Dehydrogenase Deficiency A disease-producing enzyme deficiency subject to many variants, some of which cause a deficiency of GLUCOSE-6-PHOSPHATE DEHYDROGENASE activity in erythrocytes, leading to hemolytic anemia. Deficiency of Glucose-6-Phosphate Dehydrogenase,Deficiency, GPD,Deficiency, Glucosephosphate Dehydrogenase,G6PD Deficiency,GPD Deficiency,Glucose 6 Phosphate Dehydrogenase Deficiency,Glucose-6-Phosphate Dehydrogenase Deficiency,Glucosephosphate Dehydrogenase Deficiencies,Hemolytic Anemia Due to G6PD Deficiency,Deficiencies, G6PD,Deficiencies, GPD,Deficiencies, Glucose-6-Phosphate Dehydrogenase,Deficiencies, Glucosephosphate Dehydrogenase,Deficiency of Glucose 6 Phosphate Dehydrogenase,Deficiency, G6PD,Deficiency, Glucose-6-Phosphate Dehydrogenase,Dehydrogenase Deficiencies, Glucose-6-Phosphate,Dehydrogenase Deficiencies, Glucosephosphate,Dehydrogenase Deficiency, Glucose-6-Phosphate,Dehydrogenase Deficiency, Glucosephosphate,G6PD Deficiencies,GPD Deficiencies,Glucose-6-Phosphate Dehydrogenase Deficiencies
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D014644 Genetic Variation Genotypic differences observed among individuals in a population. Genetic Diversity,Variation, Genetic,Diversity, Genetic,Diversities, Genetic,Genetic Diversities,Genetic Variations,Variations, Genetic
D017354 Point Mutation A mutation caused by the substitution of one nucleotide for another. This results in the DNA molecule having a change in a single base pair. Mutation, Point,Mutations, Point,Point Mutations

Related Publications

Hiroyuki Matsuoka, and Meiji Arai, and Shigeto Yoshida, and Indah Setyawati Tantular, and Suhintam Pusarawati, and Henyo Kerong, and Fumihiko Kawamoto
January 2006, Journal of human genetics,
Hiroyuki Matsuoka, and Meiji Arai, and Shigeto Yoshida, and Indah Setyawati Tantular, and Suhintam Pusarawati, and Henyo Kerong, and Fumihiko Kawamoto
April 1987, Biochemical genetics,
Hiroyuki Matsuoka, and Meiji Arai, and Shigeto Yoshida, and Indah Setyawati Tantular, and Suhintam Pusarawati, and Henyo Kerong, and Fumihiko Kawamoto
January 1982, Human genetics,
Hiroyuki Matsuoka, and Meiji Arai, and Shigeto Yoshida, and Indah Setyawati Tantular, and Suhintam Pusarawati, and Henyo Kerong, and Fumihiko Kawamoto
July 1989, Annals of human genetics,
Hiroyuki Matsuoka, and Meiji Arai, and Shigeto Yoshida, and Indah Setyawati Tantular, and Suhintam Pusarawati, and Henyo Kerong, and Fumihiko Kawamoto
January 2003, Human mutation,
Hiroyuki Matsuoka, and Meiji Arai, and Shigeto Yoshida, and Indah Setyawati Tantular, and Suhintam Pusarawati, and Henyo Kerong, and Fumihiko Kawamoto
October 1999, Human mutation,
Hiroyuki Matsuoka, and Meiji Arai, and Shigeto Yoshida, and Indah Setyawati Tantular, and Suhintam Pusarawati, and Henyo Kerong, and Fumihiko Kawamoto
March 1969, American journal of human genetics,
Hiroyuki Matsuoka, and Meiji Arai, and Shigeto Yoshida, and Indah Setyawati Tantular, and Suhintam Pusarawati, and Henyo Kerong, and Fumihiko Kawamoto
March 1969, Nature,
Hiroyuki Matsuoka, and Meiji Arai, and Shigeto Yoshida, and Indah Setyawati Tantular, and Suhintam Pusarawati, and Henyo Kerong, and Fumihiko Kawamoto
January 2003, Blood cells, molecules & diseases,
Hiroyuki Matsuoka, and Meiji Arai, and Shigeto Yoshida, and Indah Setyawati Tantular, and Suhintam Pusarawati, and Henyo Kerong, and Fumihiko Kawamoto
March 1995, Nihon rinsho. Japanese journal of clinical medicine,
Copied contents to your clipboard!