BIOMAT Database Logo BIOMAT Database Logo

Pediatric perfusion imaging using pulsed arterial spin labeling. 2003

Jiongjiong Wang, and Daniel J Licht, and Geon-Ho Jahng, and Chia-Shang Liu, and Joan T Rubin, and John Haselgrove, and Robert A Zimmerman, and John A Detre
Department of Radiology, University of Pennsylvania, Philadelphia 19104, USA. jwang@rad.upenn.edu

OBJECTIVE To test the feasibility of pediatric perfusion imaging using a pulsed arterial spin labeling (ASL) technique at 1.5 T. METHODS ASL perfusion imaging was carried out on seven neurologically normal children and five healthy adults. The signal-to-noise ratio (SNR) of the perfusion images along with T1, M(0), arterial transit time, and the temporal fluctuation of the ASL image series were measured and compared between the two age groups. In addition, ASL perfusion magnetic resonance (MR) was performed on three children with neurologic disorder. RESULTS In the cohort of neurologically normal children, a 70% increase in the SNR of the ASL perfusion images and a 30% increase in the absolute cerebral blood flow compared to the adult data were observed. The measures of ASL SNR, T1, and M(0) were found to decrease linearly with age. Transit time and temporal fluctuation of the ASL perfusion image series were not significantly different between the two age groups. The feasibility of ASL in the diagnosis of pediatric neurologic disease was also illustrated. CONCLUSIONS ASL is a promising tool for pediatric perfusion imaging given the unique and reciprocal benefits in terms of safety and image quality.

UI MeSH Term Description Entries
D008279 Magnetic Resonance Imaging Non-invasive method of demonstrating internal anatomy based on the principle that atomic nuclei in a strong magnetic field absorb pulses of radiofrequency energy and emit them as radiowaves which can be reconstructed into computerized images. The concept includes proton spin tomographic techniques. Chemical Shift Imaging,MR Tomography,MRI Scans,MRI, Functional,Magnetic Resonance Image,Magnetic Resonance Imaging, Functional,Magnetization Transfer Contrast Imaging,NMR Imaging,NMR Tomography,Tomography, NMR,Tomography, Proton Spin,fMRI,Functional Magnetic Resonance Imaging,Imaging, Chemical Shift,Proton Spin Tomography,Spin Echo Imaging,Steady-State Free Precession MRI,Tomography, MR,Zeugmatography,Chemical Shift Imagings,Echo Imaging, Spin,Echo Imagings, Spin,Functional MRI,Functional MRIs,Image, Magnetic Resonance,Imaging, Magnetic Resonance,Imaging, NMR,Imaging, Spin Echo,Imagings, Chemical Shift,Imagings, Spin Echo,MRI Scan,MRIs, Functional,Magnetic Resonance Images,Resonance Image, Magnetic,Scan, MRI,Scans, MRI,Shift Imaging, Chemical,Shift Imagings, Chemical,Spin Echo Imagings,Steady State Free Precession MRI
D008297 Male Males
D010477 Perfusion Treatment process involving the injection of fluid into an organ or tissue. Perfusions
D001921 Brain The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM. Encephalon
D001927 Brain Diseases Pathologic conditions affecting the BRAIN, which is composed of the intracranial components of the CENTRAL NERVOUS SYSTEM. This includes (but is not limited to) the CEREBRAL CORTEX; intracranial white matter; BASAL GANGLIA; THALAMUS; HYPOTHALAMUS; BRAIN STEM; and CEREBELLUM. Intracranial Central Nervous System Disorders,Brain Disorders,CNS Disorders, Intracranial,Central Nervous System Disorders, Intracranial,Central Nervous System Intracranial Disorders,Encephalon Diseases,Encephalopathy,Intracranial CNS Disorders,Brain Disease,Brain Disorder,CNS Disorder, Intracranial,Encephalon Disease,Encephalopathies,Intracranial CNS Disorder
D002560 Cerebrovascular Circulation The circulation of blood through the BLOOD VESSELS of the BRAIN. Brain Blood Flow,Regional Cerebral Blood Flow,Cerebral Blood Flow,Cerebral Circulation,Cerebral Perfusion Pressure,Circulation, Cerebrovascular,Blood Flow, Brain,Blood Flow, Cerebral,Brain Blood Flows,Cerebral Blood Flows,Cerebral Circulations,Cerebral Perfusion Pressures,Circulation, Cerebral,Flow, Brain Blood,Flow, Cerebral Blood,Perfusion Pressure, Cerebral,Pressure, Cerebral Perfusion
D002675 Child, Preschool A child between the ages of 2 and 5. Children, Preschool,Preschool Child,Preschool Children
D005240 Feasibility Studies Studies to determine the advantages or disadvantages, practicability, or capability of accomplishing a projected plan, study, or project. Feasibility Study,Studies, Feasibility,Study, Feasibility
D005260 Female Females
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man

Related Publications

Jiongjiong Wang, and Daniel J Licht, and Geon-Ho Jahng, and Chia-Shang Liu, and Joan T Rubin, and John Haselgrove, and Robert A Zimmerman, and John A Detre
Perfusion imaging using arterial spin labeling.
February 2004, Topics in magnetic resonance imaging : TMRI,
Jiongjiong Wang, and Daniel J Licht, and Geon-Ho Jahng, and Chia-Shang Liu, and Joan T Rubin, and John Haselgrove, and Robert A Zimmerman, and John A Detre
Quantitative perfusion imaging using arterial spin labeling.
May 1999, Neuroimaging clinics of North America,
Jiongjiong Wang, and Daniel J Licht, and Geon-Ho Jahng, and Chia-Shang Liu, and Joan T Rubin, and John Haselgrove, and Robert A Zimmerman, and John A Detre
Quantitative perfusion imaging using arterial spin labeling.
January 2006, Methods in molecular medicine,
Jiongjiong Wang, and Daniel J Licht, and Geon-Ho Jahng, and Chia-Shang Liu, and Joan T Rubin, and John Haselgrove, and Robert A Zimmerman, and John A Detre
Arterial Spin Labeling Perfusion Imaging.
February 2024, Magnetic resonance imaging clinics of North America,
Jiongjiong Wang, and Daniel J Licht, and Geon-Ho Jahng, and Chia-Shang Liu, and Joan T Rubin, and John Haselgrove, and Robert A Zimmerman, and John A Detre
Tissue specific perfusion imaging using arterial spin labeling.
March 1994, NMR in biomedicine,
Jiongjiong Wang, and Daniel J Licht, and Geon-Ho Jahng, and Chia-Shang Liu, and Joan T Rubin, and John Haselgrove, and Robert A Zimmerman, and John A Detre
Perfusion imaging using dynamic arterial spin labeling (DASL).
June 2001, Magnetic resonance in medicine,
Jiongjiong Wang, and Daniel J Licht, and Geon-Ho Jahng, and Chia-Shang Liu, and Joan T Rubin, and John Haselgrove, and Robert A Zimmerman, and John A Detre
Quantitative perfusion imaging with pulsed arterial spin labeling: a phantom study.
January 2007, Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine,
Jiongjiong Wang, and Daniel J Licht, and Geon-Ho Jahng, and Chia-Shang Liu, and Joan T Rubin, and John Haselgrove, and Robert A Zimmerman, and John A Detre
Multislice imaging of quantitative cerebral perfusion with pulsed arterial spin labeling.
May 1998, Magnetic resonance in medicine,
Jiongjiong Wang, and Daniel J Licht, and Geon-Ho Jahng, and Chia-Shang Liu, and Joan T Rubin, and John Haselgrove, and Robert A Zimmerman, and John A Detre
Regional reproducibility of pulsed arterial spin labeling perfusion imaging at 3T.
January 2011, NeuroImage,
Jiongjiong Wang, and Daniel J Licht, and Geon-Ho Jahng, and Chia-Shang Liu, and Joan T Rubin, and John Haselgrove, and Robert A Zimmerman, and John A Detre
Implementation of quantitative perfusion imaging using pulsed arterial spin labeling at ultra-high field.
April 2009, Magnetic resonance in medicine,
Copied contents to your clipboard!