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Synthesis of carbocyclic and acyclic nucleosides possessing 2-fluoroadenine derivatives and their inhibitory activities against Plasmodium falciparum SAH hydrolase. 2003
Yukio Kitade, and
Hiroharu Kojima, and
Fazila Zulfiqur, and
Saori Yabe, and
Daisuke Yamagiwa, and
Yasutomo Ito, and
Masayuki Nakanishi, and
Yoshihito Ueno, and
Hye-Sook Kim, and
Yusuke Wataya
Department of Biomolecular Science, Faculty of Engineering, Gifu University, Yanagido, Gifu 501-1193, Japan.
Carbocyclic and acyclic nucleosides possessing 2-fluoroadenine, such as 2-fluoronoraristeromycin (6) and 2-fluoro-9-[(2S,3R)-2,3,4-trihydroxy-butyl-1-yl]adenine (8), were synthesized and their inhibitory activities against human and Plasmodium falciparum recombinant SAH hydrolase were investigated.
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