Biomaterial Database

Proximal arterial occlusion protects the distal lower limb vessels. 2003

M Wijendra, and D Dodd, and N Chalmers

Department of Radiology, Manchester Royal Infirmary, Manchester, UK.

OBJECTIVE To test the hypothesis that chronic arterial occlusion protects the distal vessels from disease progression. METHODS Peripheral angiograms from the radiology film store filed under 1997-1999 were reviewed. Those showing unilateral iliac occlusion and those showing unilateral femoro-popliteal occlusion were selected. The severity of arterial disease distal to the occlusion was compared with the patent side. Subsequently, in a subgroup of patients undergoing repeat angiography, the frequency and distribution of disease progression was recorded and related to the initial disease distribution. RESULTS In the presence of a unilateral iliac occlusion, femoro-popliteal occlusion was less likely on the side of the iliac occlusion than on the opposite side (difference in proportion 10%. 95% C.I.: 1-18%). In the presence of a unilateral occlusion proximal to the knee joint, there were more patent calf vessels on the side of the occlusion than on the opposite side (difference in proportion 9%. 95% C.I.: 4-14%). When angiography was repeated, progression of calf vessel disease was less common in the limbs with untreated proximal occlusion than in those with no proximal occlusion. CONCLUSIONS Proximal arterial occlusion protects the distal vessels from the risk of progressive arterial disease.

UI	MeSH Term	Description	Entries
D007083	Iliac Artery	Either of two large arteries originating from the abdominal aorta; they supply blood to the pelvis, abdominal wall and legs.	Deep Circumflex Iliac Artery,Arteries, Iliac,Artery, Iliac,Iliac Arteries
D007866	Leg	The inferior part of the lower extremity between the KNEE and the ANKLE.	Legs
D011150	Popliteal Artery	The continuation of the femoral artery coursing through the popliteal fossa; it divides into the anterior and posterior tibial arteries.	Arteria Poplitea,Artery, Popliteal,Popliteal Arteries
D002908	Chronic Disease	Diseases which have one or more of the following characteristics: they are permanent, leave residual disability, are caused by nonreversible pathological alteration, require special training of the patient for rehabilitation, or may be expected to require a long period of supervision, observation, or care (Dictionary of Health Services Management, 2d ed). For epidemiological studies chronic disease often includes HEART DISEASES; STROKE; CANCER; and diabetes (DIABETES MELLITUS, TYPE 2).	Chronic Condition,Chronic Illness,Chronically Ill,Chronic Conditions,Chronic Diseases,Chronic Illnesses,Condition, Chronic,Disease, Chronic,Illness, Chronic
D005263	Femoral Artery	The main artery of the thigh, a continuation of the external iliac artery.	Common Femoral Artery,Arteries, Common Femoral,Arteries, Femoral,Artery, Common Femoral,Artery, Femoral,Common Femoral Arteries,Femoral Arteries,Femoral Arteries, Common,Femoral Artery, Common
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D001157	Arterial Occlusive Diseases	Pathological processes which result in the partial or complete obstruction of ARTERIES. They are characterized by greatly reduced or absence of blood flow through these vessels. They are also known as arterial insufficiency.	Arterial Obstructive Diseases,Arterial Occlusion,Arterial Obstructive Disease,Arterial Occlusions,Arterial Occlusive Disease,Disease, Arterial Obstructive,Disease, Arterial Occlusive,Obstructive Disease, Arterial,Occlusion, Arterial,Occlusive Disease, Arterial
D012189	Retrospective Studies	Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.	Retrospective Study,Studies, Retrospective,Study, Retrospective
D015901	Angiography, Digital Subtraction	A method of delineating blood vessels by subtracting a tissue background image from an image of tissue plus intravascular contrast material that attenuates the X-ray photons. The background image is determined from a digitized image taken a few moments before injection of the contrast material. The resulting angiogram is a high-contrast image of the vessel. This subtraction technique allows extraction of a high-intensity signal from the superimposed background information. The image is thus the result of the differential absorption of X-rays by different tissues.	Digital Subtraction Angiography,Subtraction Angiography, Digital
D018450	Disease Progression	The worsening and general progression of a disease over time. This concept is most often used for chronic and incurable diseases where the stage of the disease is an important determinant of therapy and prognosis.	Clinical Course,Clinical Progression,Disease Exacerbation,Exacerbation, Disease,Progression, Clinical,Progression, Disease