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Technetium-99 m (99mTc)-labelled conjugates of an anti-fibrin monoclonal antibody, DD-3B6/22, have been assessed for their detection of vascular thrombi in a rabbit model. DD-3B6/22 binds to a D-dimer epitope present on cross-linked fibrin but absent from the fibrin monomer or fibrinogen. Injection of a 99mTc-labelled Fab' fragment of DD-3B6/22 allowed delineation of model thrombi as early as 30 min postinjection (p.i.) with optimal localization at 4-5 h. Thrombus label uptake at 4 h p.i. was 0.304 +/- 0.106% injected dose/g (% ID/g) compared with 0.022 +/- 0.001% ID/g after the injection of a control Fab' fragment. These results suggest that the 99mTc-labelled Fab' fragment of DD-3B6/22 has excellent potential for scintigraphic detection of vascular thrombi in humans.
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P G Bundesen, and
D B Rylatt, and
K Z Walker
June 1992,
Journal of nuclear medicine : official publication, Society of Nuclear Medicine,
F T Lee, and
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K Z Walker
February 1995,
British journal of urology,
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June 1996,
European journal of nuclear medicine,
F T Lee, and
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August 1993,
European journal of nuclear medicine,
F T Lee, and
L J Milner, and
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November 1993,
European journal of nuclear medicine,
F T Lee, and
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June 1993,
European journal of nuclear medicine,
F T Lee, and
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September 1994,
Journal of nuclear medicine : official publication, Society of Nuclear Medicine,
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February 1994,
Journal of nuclear medicine : official publication, Society of Nuclear Medicine,
F T Lee, and
L J Milner, and
G R Boniface, and
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P G Bundesen, and
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K Z Walker
July 1990,
The British journal of cancer. Supplement,
F T Lee, and
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January 1998,
Zhonghua wai ke za zhi [Chinese journal of surgery],
