Sexual dimorphism and postnatal growth of intrauterine growth retarded rats. 2003

Evelia E Oyhenart, and Bibiana Orden, and María C Fucini, and María C Muñe, and Héctor M Pucciarelli
Centro de Investigaciones en Genética Básica y Aplicada, Facultad de Ciencias Veterinarias, Universidad Nacional de La Plata, Argentina. eoyenart@fcv.unlp.edu.ar

The intrauterine growth retardation (IUGR) is a complex phenomenon since it causes variability in postnatal growth responses. The aim of the present study was to analyze the effects of lactational rehabilitation on body and cranial growth and sexual dimorphism in IUGR rats. IUGR model was carried out by means of uterine vessels bending in pregnant rats at the first day of pregnancy. Control and sham-operated animals were also included. During suckling, IUGR and sham-operated pups were cross-fostered to a control dam. The animals were x-rayed every four days, from birth to weaning. Body weight and length, and neural and facial variables were measured. The reduced placental blood flow delayed growth in pups. Facial growth was more impaired than the neural one. An incomplete catch up growth was found, since males reached sham values only in neurocranial height and females--except facial length and width--were similar to sham. Because of sex differences in growth recovery, normal sexual dimorphism in body and craniofacial pattern was not expressed in the IUGR group. This study suggests that reduced uteroplacental blood supply in the rat interferes with the full expression of normal dimorphism based on gender and confirms the impact of IUGR on postnatal growth.

UI MeSH Term Description Entries
D007774 Lactation The processes of milk secretion by the maternal MAMMARY GLANDS after PARTURITION. The proliferation of the mammary glandular tissue, milk synthesis, and milk expulsion or let down are regulated by the interactions of several hormones including ESTRADIOL; PROGESTERONE; PROLACTIN; and OXYTOCIN. Lactation, Prolonged,Milk Secretion,Lactations, Prolonged,Milk Secretions,Prolonged Lactation,Prolonged Lactations
D008297 Male Males
D009420 Nervous System The entire nerve apparatus, composed of a central part, the brain and spinal cord, and a peripheral part, the cranial and spinal nerves, autonomic ganglia, and plexuses. (Stedman, 26th ed) Nervous Systems,System, Nervous,Systems, Nervous
D011247 Pregnancy The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH. Gestation,Pregnancies
D001824 Body Constitution The physical characteristics of the body, including the mode of performance of functions, the activity of metabolic processes, the manner and degree of reactions to stimuli, and power of resistance to the attack of pathogenic organisms. Body Constitutions,Constitution, Body,Constitutions, Body
D001835 Body Weight The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms. Body Weights,Weight, Body,Weights, Body
D005147 Facial Bones The facial skeleton, consisting of bones situated between the cranial base and the mandibular region. While some consider the facial bones to comprise the hyoid (HYOID BONE), palatine (HARD PALATE), and zygomatic (ZYGOMA) bones, MANDIBLE, and MAXILLA, others include also the lacrimal and nasal bones, inferior nasal concha, and vomer but exclude the hyoid bone. (Jablonski, Dictionary of Dentistry, 1992, p113) Bone, Facial,Bones, Facial,Facial Bone
D005260 Female Females
D005317 Fetal Growth Retardation Failure of a FETUS to attain expected GROWTH. Growth Retardation, Intrauterine,Intrauterine Growth Retardation,Fetal Growth Restriction,Intrauterine Growth Restriction
D000375 Aging The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time. Senescence,Aging, Biological,Biological Aging

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