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Using stereological techniques capillaries, interstitium and myocardial fibers were analyzed in perfusion-fixed hearts of subtotally nephrectomized male Sprague-Dawley rats with uremia of 14 months duration (or their sham-operated controls). Uremic rats had higher systolic blood pressure (140 +/- 20.3 mm Hg vs. 119 +/- 6.61 mm Hg) and left ventricular weight/body weight ratio (3.37 +/- 0.09 mg/kg vs. 2.01 +/- 0.12 mg/kg) than controls, and had slight anemia (Hct 35.0 +/- 3.16% vs. 40.4 +/- 3.3%). Length density (Lv) of capillaries, that is, capillary length per unit myocardial volume, was significantly (P < 0.001) decreased in uremia (2485 +/- 264 mm/mm3 vs. 3329 +/- 194 mm/mm3) versus controls. In parallel, surface density and volume density of the capillary lumina were also reduced (7.95 +/- 1.69 cm3/cm3 vs. 11.4 +/- 1.8 cm3/cm3) in the uremic rats. We conclude that in experimental uremia, cardiac hypertrophy is not accompanied by a commensurate increase in capillaries.
K Amann, and
G Wiest, and
G Zimmer, and
N Gretz, and
E Ritz, and
G Mall
September 2002,
Journal of cardiovascular pharmacology,
K Amann, and
G Wiest, and
G Zimmer, and
N Gretz, and
E Ritz, and
G Mall
June 1992,
Zhonghua bing li xue za zhi = Chinese journal of pathology,
K Amann, and
G Wiest, and
G Zimmer, and
N Gretz, and
E Ritz, and
G Mall
November 1998,
Zhonghua zheng xing shao shang wai ke za zhi = Zhonghua zheng xing shao shang waikf [i.e. waike] zazhi = Chinese journal of plastic surgery and burns,
K Amann, and
G Wiest, and
G Zimmer, and
N Gretz, and
E Ritz, and
G Mall
May 2005,
Acta neuropathologica,
K Amann, and
G Wiest, and
G Zimmer, and
N Gretz, and
E Ritz, and
G Mall
January 1984,
Acta cardiologica,
K Amann, and
G Wiest, and
G Zimmer, and
N Gretz, and
E Ritz, and
G Mall
October 1993,
Biulleten' eksperimental'noi biologii i meditsiny,
K Amann, and
G Wiest, and
G Zimmer, and
N Gretz, and
E Ritz, and
G Mall
February 1982,
The American journal of physiology,
K Amann, and
G Wiest, and
G Zimmer, and
N Gretz, and
E Ritz, and
G Mall
November 1989,
The American review of respiratory disease,
K Amann, and
G Wiest, and
G Zimmer, and
N Gretz, and
E Ritz, and
G Mall
November 2012,
The Journal of comparative neurology,
K Amann, and
G Wiest, and
G Zimmer, and
N Gretz, and
E Ritz, and
G Mall
March 2019,
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation,
