Biomaterial Database

Teratogenic effects of 6-aminonicotinamide in mice. 1977

G H Matschke, and K A Fagerstone

6-Aminonicotinamide (6-AN), a potential broad-spectrum rodenticide, was examined for embryotoxic and teratogenic potential. Mice of the BALB/c strain were given a single oral dose of 1, 17, 34, 51 or 136 mg/kg on one of days 8 to 13 of gestation. Fetuses were either examined on day 18 post coitum (prenatal study), or allowed to go to term and examined 2 days after birth. Dam weights were significantly reduced (p less than 0.01) at dose levels of 17 mg/kg and greater. These same dose levels caused a significant decrease (p less than 0.01) in litter size and in mean fetal weight. They also caused an increase in the number of resorptions. Hydrocephalus and cleft palate were the most frequent visceral anomalies and were dose-dependent. Skeletal anomalies were also dose-dependent, and the fetus was most susceptible on days 8 to 10 post coitum. A significant (p less than 0.05) increase in the ratio of female to male fetuses was observed at dose levels of 34 mg/kg and greater. Surviving 2-day-old pups had few visceral anomalies but skeletal anomalies were more frequent. Because of its teratogenic properties, it would be difficult to register 6-AN for use against commensal rodents or as a broad-spectrum rodenticide for use in agricultural crops.

UI	MeSH Term	Description	Entries
D008297	Male		Males
D008807	Mice, Inbred BALB C	An inbred strain of mouse that is widely used in IMMUNOLOGY studies and cancer research.	BALB C Mice, Inbred,BALB C Mouse, Inbred,Inbred BALB C Mice,Inbred BALB C Mouse,Mice, BALB C,Mouse, BALB C,Mouse, Inbred BALB C,BALB C Mice,BALB C Mouse
D009536	Niacinamide	An important compound functioning as a component of the coenzyme NAD. Its primary significance is in the prevention and/or cure of blacktongue and PELLAGRA. Most animals cannot manufacture this compound in amounts sufficient to prevent nutritional deficiency and it therefore must be supplemented through dietary intake.	Nicotinamide,Vitamin B 3,Vitamin PP,3-Pyridinecarboxamide,Enduramide,Nicobion,Nicotinsäureamid Jenapharm,Papulex,Vitamin B3,3 Pyridinecarboxamide,B 3, Vitamin,B3, Vitamin,Jenapharm, Nicotinsäureamid
D005260	Female		Females
D005333	Fetus	The unborn young of a viviparous mammal, in the postembryonic period, after the major structures have been outlined. In humans, the unborn young from the end of the eighth week after CONCEPTION until BIRTH, as distinguished from the earlier EMBRYO, MAMMALIAN.	Fetal Structures,Fetal Tissue,Fetuses,Mummified Fetus,Retained Fetus,Fetal Structure,Fetal Tissues,Fetus, Mummified,Fetus, Retained,Structure, Fetal,Structures, Fetal,Tissue, Fetal,Tissues, Fetal
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D013723	Teratogens	An agent that causes the production of physical defects in the developing embryo.	Embryotoxins,Fetotoxins,Teratogen
D013997	Time Factors	Elements of limited time intervals, contributing to particular results or situations.	Time Series,Factor, Time,Time Factor
D015120	6-Aminonicotinamide	A vitamin antagonist which has teratogenic effects.	6 Aminonicotinamide
D051379	Mice	The common name for the genus Mus.	Mice, House,Mus,Mus musculus,Mice, Laboratory,Mouse,Mouse, House,Mouse, Laboratory,Mouse, Swiss,Mus domesticus,Mus musculus domesticus,Swiss Mice,House Mice,House Mouse,Laboratory Mice,Laboratory Mouse,Mice, Swiss,Swiss Mouse,domesticus, Mus musculus