BIOMAT Database Logo BIOMAT Database Logo

Partial molar volumes of mRNA 5' cap analogues. 2003

Jedrzej Szymanski, and Janusz Stepinski, and Jaroslaw Poznanski, and Edward Darzynkiewicz, and Wojciech Zielenkiewicz, and Ryszard Stolarski
Department of Biophysics, Institute of Experimental Physics, Warsaw University, Warszawa, Poland.

Partial molar volumes in aqueous solution of eleven selected 7-methylguanine cap-analogues and their guanine counterparts were determined by means of density measurements. Hydrophobicity of the investigated compounds regarding their structural features was analysed within the framework of the solute-solvent interaction model, based on the relative density of the molecular solvation shell.

UI MeSH Term Description Entries
D009690 Nucleic Acid Conformation The spatial arrangement of the atoms of a nucleic acid or polynucleotide that results in its characteristic 3-dimensional shape. DNA Conformation,RNA Conformation,Conformation, DNA,Conformation, Nucleic Acid,Conformation, RNA,Conformations, DNA,Conformations, Nucleic Acid,Conformations, RNA,DNA Conformations,Nucleic Acid Conformations,RNA Conformations
D006147 Guanine
D006157 Guanosine Monophosphate A guanine nucleotide containing one phosphate group esterified to the sugar moiety and found widely in nature. 5'-Guanylic Acid,Guanosine 5'-Monophosphate,5'-GMP,Guanylic Acid,5' Guanylic Acid,5'-Monophosphate, Guanosine,Acid, 5'-Guanylic,Acid, Guanylic,Guanosine 5' Monophosphate,Monophosphate, Guanosine
D012315 RNA Caps Nucleic acid structures found on the 5' end of eukaryotic cellular and viral messenger RNA and some heterogeneous nuclear RNAs. These structures, which are positively charged, protect the above specified RNAs at their termini against attack by phosphatases and other nucleases and promote mRNA function at the level of initiation of translation. Analogs of the RNA caps (RNA CAP ANALOGS), which lack the positive charge, inhibit the initiation of protein synthesis. RNA Cap,5' Capped RNA,5' mRNA Cap Structure,Cap, RNA,Caps, RNA,RNA, 5' Capped
D013329 Structure-Activity Relationship The relationship between the chemical structure of a compound and its biological or pharmacological activity. Compounds are often classed together because they have structural characteristics in common including shape, size, stereochemical arrangement, and distribution of functional groups. Relationship, Structure-Activity,Relationships, Structure-Activity,Structure Activity Relationship,Structure-Activity Relationships

Related Publications

Jedrzej Szymanski, and Janusz Stepinski, and Jaroslaw Poznanski, and Edward Darzynkiewicz, and Wojciech Zielenkiewicz, and Ryszard Stolarski
Photocaged 5' cap analogues for optical control of mRNA translation in cells.
August 2022, Nature chemistry,
Jedrzej Szymanski, and Janusz Stepinski, and Jaroslaw Poznanski, and Edward Darzynkiewicz, and Wojciech Zielenkiewicz, and Ryszard Stolarski
Decapping Scavenger Enzyme Activity toward N2-Substituted 5' End mRNA Cap Analogues.
October 2019, ACS omega,
Jedrzej Szymanski, and Janusz Stepinski, and Jaroslaw Poznanski, and Edward Darzynkiewicz, and Wojciech Zielenkiewicz, and Ryszard Stolarski
Isoxazole-containing 5' mRNA cap analogues as inhibitors of the translation initiation process.
March 2020, Bioorganic chemistry,
Jedrzej Szymanski, and Janusz Stepinski, and Jaroslaw Poznanski, and Edward Darzynkiewicz, and Wojciech Zielenkiewicz, and Ryszard Stolarski
Exploring the potential of phosphotriazole 5' mRNA cap analogues as efficient translation initiators.
September 2018, Organic & biomolecular chemistry,
Jedrzej Szymanski, and Janusz Stepinski, and Jaroslaw Poznanski, and Edward Darzynkiewicz, and Wojciech Zielenkiewicz, and Ryszard Stolarski
The standard partial molar volumes of ions in solution. Part 5. Ionic volumes in water at 125-200 °C.
June 2012, The journal of physical chemistry. B,
Jedrzej Szymanski, and Janusz Stepinski, and Jaroslaw Poznanski, and Edward Darzynkiewicz, and Wojciech Zielenkiewicz, and Ryszard Stolarski
Assignment of the absolute configuration of P-chiral 5' mRNA cap analogues containing phosphorothioate moiety.
January 2007, Nucleosides, nucleotides & nucleic acids,
Jedrzej Szymanski, and Janusz Stepinski, and Jaroslaw Poznanski, and Edward Darzynkiewicz, and Wojciech Zielenkiewicz, and Ryszard Stolarski
Partial Molar Volumes of Aqua Ions from First Principles.
August 2017, Journal of chemical theory and computation,
Jedrzej Szymanski, and Janusz Stepinski, and Jaroslaw Poznanski, and Edward Darzynkiewicz, and Wojciech Zielenkiewicz, and Ryszard Stolarski
The partial molar volumes of anesthetics in lipid bilayers.
September 1981, Biochimica et biophysica acta,
Jedrzej Szymanski, and Janusz Stepinski, and Jaroslaw Poznanski, and Edward Darzynkiewicz, and Wojciech Zielenkiewicz, and Ryszard Stolarski
Partial Molar Volumes of 15-Crown-5 Ether in Mixtures of N,N-Dimethylformamide with Water.
January 2014, Journal of solution chemistry,
Jedrzej Szymanski, and Janusz Stepinski, and Jaroslaw Poznanski, and Edward Darzynkiewicz, and Wojciech Zielenkiewicz, and Ryszard Stolarski
Partial molar volumes and adiabatic compressibilities of unfolded protein states.
May 2008, Biophysical chemistry,
Copied contents to your clipboard!