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[Unrelated HLA-mismatched cord blood transplantation using nonmyeloablative conditioning in an adult patient with very severe aplastic anemia]. 2003
Yasuhiko Miyazaki, and
Naoto Nakamichi, and
Noriaki Matsumoto, and
Katsuhiro Zen, and
Ryuichi Amakawa, and
Yuji Kishimoto, and
Shirou Fukuhara
First Department of Internal Medicine, Kansai Medical University.
An adult patient suffering from G-CSF-resistant very severe aplastic anemia received a cord blood transplantation from a three-loci HLA-mismatched unrelated donor after nonmyeloablative conditioning. Cord blood was infused after conditioning with fludarabine (180 mg/m2) and cyclophosphamide (100 mg/kg). Cyclosporin A and short-term methotrexate were used for prophylaxis against acute GVHD. Engraftment was achieved on day 23, and there was no serious GVHD. A full-donor type T-cell chimerism was obtained by day 30. Normal hematopoiesis and complete chimerism have been maintained 14 months after transplantation.
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