BIOMAT Database Logo BIOMAT Database Logo

Fibronectin promotes lung colony formation in the mouse by B16 melanoma cells spheroids. 1992

P Coucke, and M C De Pauw-Gillet, and L De Leval, and A Noel, and R Bassleer, and J M Foidart
Laboratory of Biology, University of Liège, Belgium.

By microscopical observation and using an original method of automatic image analysis, we studied on histological sections the rate of lung colony formation after intravenous injection into the mouse of B16 melanoma cells previously cultivated in vitro as pure or mixed spheroids (B16 + 3T3 fibroblasts). The preincubation in vitro of pure spheroids with fibronectin significantly increased the percentages of lung section area occupied by tumors and the relative number of internal lung colonies. This effect of fibronectin was even more obvious when mixed spheroids were injected.

UI MeSH Term Description Entries
D007091 Image Processing, Computer-Assisted A technique of inputting two-dimensional or three-dimensional images into a computer and then enhancing or analyzing the imagery into a form that is more useful to the human observer. Biomedical Image Processing,Computer-Assisted Image Processing,Digital Image Processing,Image Analysis, Computer-Assisted,Image Reconstruction,Medical Image Processing,Analysis, Computer-Assisted Image,Computer-Assisted Image Analysis,Computer Assisted Image Analysis,Computer Assisted Image Processing,Computer-Assisted Image Analyses,Image Analyses, Computer-Assisted,Image Analysis, Computer Assisted,Image Processing, Biomedical,Image Processing, Computer Assisted,Image Processing, Digital,Image Processing, Medical,Image Processings, Medical,Image Reconstructions,Medical Image Processings,Processing, Biomedical Image,Processing, Digital Image,Processing, Medical Image,Processings, Digital Image,Processings, Medical Image,Reconstruction, Image,Reconstructions, Image
D007275 Injections, Intravenous Injections made into a vein for therapeutic or experimental purposes. Intravenous Injections,Injection, Intravenous,Intravenous Injection
D008175 Lung Neoplasms Tumors or cancer of the LUNG. Cancer of Lung,Lung Cancer,Pulmonary Cancer,Pulmonary Neoplasms,Cancer of the Lung,Neoplasms, Lung,Neoplasms, Pulmonary,Cancer, Lung,Cancer, Pulmonary,Cancers, Lung,Cancers, Pulmonary,Lung Cancers,Lung Neoplasm,Neoplasm, Lung,Neoplasm, Pulmonary,Pulmonary Cancers,Pulmonary Neoplasm
D008546 Melanoma, Experimental Experimentally induced tumor that produces MELANIN in animals to provide a model for studying human MELANOMA. B16 Melanoma,Melanoma, B16,Melanoma, Cloudman S91,Melanoma, Harding-Passey,Experimental Melanoma,Experimental Melanomas,Harding Passey Melanoma,Melanomas, Experimental,B16 Melanomas,Cloudman S91 Melanoma,Harding-Passey Melanoma,Melanoma, Harding Passey,Melanomas, B16,S91 Melanoma, Cloudman
D008810 Mice, Inbred C57BL One of the first INBRED MOUSE STRAINS to be sequenced. This strain is commonly used as genetic background for transgenic mouse models. Refractory to many tumors, this strain is also preferred model for studying role of genetic variations in development of diseases. Mice, C57BL,Mouse, C57BL,Mouse, Inbred C57BL,C57BL Mice,C57BL Mice, Inbred,C57BL Mouse,C57BL Mouse, Inbred,Inbred C57BL Mice,Inbred C57BL Mouse
D009360 Neoplastic Cells, Circulating Exfoliate neoplastic cells circulating in the blood and associated with metastasizing tumors. Circulating Neoplastic Cells,Embolic Tumor Cells,Embolism, Tumor,Neoplasm Circulating Cells,Tumor Cells, Embolic,Cells, Neoplasm Circulating,Circulating Cells, Neoplasm,Circulating Tumor Cells,Cell, Circulating Neoplastic,Cell, Circulating Tumor,Cell, Embolic Tumor,Cell, Neoplasm Circulating,Cells, Circulating Neoplastic,Cells, Circulating Tumor,Cells, Embolic Tumor,Circulating Neoplastic Cell,Circulating Tumor Cell,Embolic Tumor Cell,Embolisms, Tumor,Neoplasm Circulating Cell,Neoplastic Cell, Circulating,Tumor Cell, Circulating,Tumor Cell, Embolic,Tumor Cells, Circulating,Tumor Embolism,Tumor Embolisms
D009368 Neoplasm Transplantation Experimental transplantation of neoplasms in laboratory animals for research purposes. Transplantation, Neoplasm,Neoplasm Transplantations,Transplantations, Neoplasm
D009940 Organoids An organization of cells into an organ-like structure. Organoids can be generated in culture, e.g., self-organized three-dimensional tissue structures derived from STEM CELLS (see MICROPHYSIOLOGICAL SYSTEMS). They are also found in certain NEOPLASMS. Organoid
D002478 Cells, Cultured Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others. Cultured Cells,Cell, Cultured,Cultured Cell
D005353 Fibronectins Glycoproteins found on the surfaces of cells, particularly in fibrillar structures. The proteins are lost or reduced when these cells undergo viral or chemical transformation. They are highly susceptible to proteolysis and are substrates for activated blood coagulation factor VIII. The forms present in plasma are called cold-insoluble globulins. Cold-Insoluble Globulins,LETS Proteins,Fibronectin,Opsonic Glycoprotein,Opsonic alpha(2)SB Glycoprotein,alpha 2-Surface Binding Glycoprotein,Cold Insoluble Globulins,Globulins, Cold-Insoluble,Glycoprotein, Opsonic,Proteins, LETS,alpha 2 Surface Binding Glycoprotein

Related Publications

P Coucke, and M C De Pauw-Gillet, and L De Leval, and A Noel, and R Bassleer, and J M Foidart
The lung-colony assay: extension to the Lewis lung tumour and the B16 melanoma--radiosensitivity of B16 melanoma cells.
April 1975, International journal of radiation biology and related studies in physics, chemistry, and medicine,
P Coucke, and M C De Pauw-Gillet, and L De Leval, and A Noel, and R Bassleer, and J M Foidart
Plectin promotes tumor formation by B16 mouse melanoma cells via regulation of Rous sarcoma oncogene activity.
August 2022, BMC cancer,
P Coucke, and M C De Pauw-Gillet, and L De Leval, and A Noel, and R Bassleer, and J M Foidart
Prevention of melanin formation by yeast cerebroside in B16 mouse melanoma cells.
January 2007, Journal of oleo science,
P Coucke, and M C De Pauw-Gillet, and L De Leval, and A Noel, and R Bassleer, and J M Foidart
Laminin and fibronectin promote the haptotactic migration of B16 mouse melanoma cells in vitro.
April 1984, The Journal of cell biology,
P Coucke, and M C De Pauw-Gillet, and L De Leval, and A Noel, and R Bassleer, and J M Foidart
DMSO-induced changes in the procoagulant and fibrinolytic activity of B16 melanoma cells: influence on lung colony formation.
January 1988, Clinical & experimental metastasis,
P Coucke, and M C De Pauw-Gillet, and L De Leval, and A Noel, and R Bassleer, and J M Foidart
Narrow-band UVB radiation promotes dendrite formation by activating Rac1 in B16 melanoma cells.
September 2013, Molecular and clinical oncology,
P Coucke, and M C De Pauw-Gillet, and L De Leval, and A Noel, and R Bassleer, and J M Foidart
Augmentation of B16 melanoma lung colony formation in C57BL/6 mice having marked granulocytosis.
June 1986, International journal of cancer,
P Coucke, and M C De Pauw-Gillet, and L De Leval, and A Noel, and R Bassleer, and J M Foidart
Metalloproteinases and serine proteases activities in mixed spheroids of mouse b16 melanoma-cells and fibroblasts.
November 1994, International journal of oncology,
P Coucke, and M C De Pauw-Gillet, and L De Leval, and A Noel, and R Bassleer, and J M Foidart
Fibronectin enhancement of directed migration of B16 melanoma cells.
April 1984, Cancer research,
P Coucke, and M C De Pauw-Gillet, and L De Leval, and A Noel, and R Bassleer, and J M Foidart
Methyl p-coumarate, a melanin formation inhibitor in B16 mouse melanoma cells.
October 2004, Bioorganic & medicinal chemistry,
Copied contents to your clipboard!