Biomaterial Database

[Antiallergic asthma effect of ipatropium bromide (Sch 1000) in dogs (author's transl)]. 1977

Y Yamatake, and S Sasagawa, and S Yanaura, and Y Okamiya

Antiasthmatic effect of ipratropium bromide (Sch 1000) which is a quarternary ammonium derivative of atropine was investigated in comparison with atropine in anesthetized dogs. Asthmatic responses were provoked with inhalation of Ascaris suum antigen. Sch 1000 (0.1 approximately 0.3%) and atropine (0.1 approximately 0.3%) were given by inhalation for 10 min prior to or after the antigen inhalation. Pretreatment of Sch 1000 and atropine inhibited the increase in respiratory resistance (Rrs) induced by antigen by 55 approximately 75% and 25 approximately 50%, respectively. After treatment with each drug, the enhanced Rrs was reduced by 40 approximately 55% and 35 approximately 40%, respectively. The activity of Sch 1000 was three fold stronger than that of atropine. Sch 1000 and atropine also effectively inhibited the increase in airway secretion produced by antigen, while both drugs in 0.3% solution had no effect on the normal bronchial tone and secretion. The findings suggest that vagal activity is involved in allergy related asthma and inhalations of anticholinergic drugs such as Sch 1000 show promise in the treatment of bronchial asthma.

UI	MeSH Term	Description	Entries
D008297	Male		Males
D009241	Ipratropium	A muscarinic antagonist structurally related to ATROPINE but often considered safer and more effective for inhalation use. It is used for various bronchial disorders, in rhinitis, and as an antiarrhythmic.	N-Isopropylatropine,(endo,syn)-(+-)-3-(3-Hydroxy-1-oxo-2-phenylpropoxy)-8-methyl-8-(1-methylethyl)-8-azoniabicyclo(3.2.1)octane,Atrovent,Ipratropium Bromide,Ipratropium Bromide Anhydrous,Ipratropium Bromide Monohydrate,Ipratropium Bromide, (endo,anti)-Isomer,Ipratropium Bromide, (exo,syn)-Isomer,Ipratropium Bromide, endo-Isomer,Itrop,Sch-1000,Sch-1178,N Isopropylatropine,Sch 1000,Sch 1178,Sch1000,Sch1178
D004285	Dogs	The domestic dog, Canis familiaris, comprising about 400 breeds, of the carnivore family CANIDAE. They are worldwide in distribution and live in association with people. (Walker's Mammals of the World, 5th ed, p1065)	Canis familiaris,Dog
D000403	Airway Resistance	Physiologically, the opposition to flow of air caused by the forces of friction. As a part of pulmonary function testing, it is the ratio of driving pressure to the rate of air flow.	Airway Resistances,Resistance, Airway,Resistances, Airway
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D000941	Antigens	Substances that are recognized by the immune system and induce an immune reaction.	Antigen
D001200	Ascaris	A genus of nematodes of the superfamily ASCARIDOIDEA whose species usually inhabit the intestine.	Ascari
D001249	Asthma	A form of bronchial disorder with three distinct components: airway hyper-responsiveness (RESPIRATORY HYPERSENSITIVITY), airway INFLAMMATION, and intermittent AIRWAY OBSTRUCTION. It is characterized by spasmodic contraction of airway smooth muscle, WHEEZING, and dyspnea (DYSPNEA, PAROXYSMAL).	Asthma, Bronchial,Bronchial Asthma,Asthmas
D001285	Atropine	An alkaloid, originally from Atropa belladonna, but found in other plants, mainly SOLANACEAE. Hyoscyamine is the 3(S)-endo isomer of atropine.	AtroPen,Atropin Augenöl,Atropine Sulfate,Atropine Sulfate Anhydrous,Atropinol,Anhydrous, Atropine Sulfate,Augenöl, Atropin,Sulfate Anhydrous, Atropine,Sulfate, Atropine
D001286	Atropine Derivatives	Analogs and derivatives of atropine.	Atropines