BIOMAT Database Logo BIOMAT Database Logo

Restraint, seclusion, and clozapine. 1992

A R Mallya, and P D Roos, and K Roebuck-Colgan
Missouri Department of Mental Health, Jefferson City 65102.

BACKGROUND The effects of clozapine, an unconventional neuroleptic drug, on the use of restraint and seclusion in patients have not been extensively reported on in the United States. METHODS The records of 107 patients receiving clozapine in Missouri state mental hospitals were reviewed over a 13-month period for frequency and duration of restraint and seclusion. RESULTS During clozapine treatment, patients had fewer episodes of restraint and seclusion than previously. The duration of restraints and seclusions also decreased, starting the second month after the initiation of clozapine treatment. CONCLUSIONS For patients who were restrained or secluded before clozapine treatment, the decrease in the number and duration of restraint and seclusion episodes was dramatic.

UI MeSH Term Description Entries
D012149 Restraint, Physical Use of a device for the purpose of controlling movement of all or part of the body. Splinting and casting are FRACTURE FIXATION. Immobilization, Physical,Physical Restraint,Physical Immobilization,Physical Restraints,Restraints, Physical
D002908 Chronic Disease Diseases which have one or more of the following characteristics: they are permanent, leave residual disability, are caused by nonreversible pathological alteration, require special training of the patient for rehabilitation, or may be expected to require a long period of supervision, observation, or care (Dictionary of Health Services Management, 2d ed). For epidemiological studies chronic disease often includes HEART DISEASES; STROKE; CANCER; and diabetes (DIABETES MELLITUS, TYPE 2). Chronic Condition,Chronic Illness,Chronically Ill,Chronic Conditions,Chronic Diseases,Chronic Illnesses,Condition, Chronic,Disease, Chronic,Illness, Chronic
D003024 Clozapine A tricylic dibenzodiazepine, classified as an atypical antipsychotic agent. It binds several types of central nervous system receptors, and displays a unique pharmacological profile. Clozapine is a serotonin antagonist, with strong binding to 5-HT 2A/2C receptor subtype. It also displays strong affinity to several dopaminergic receptors, but shows only weak antagonism at the dopamine D2 receptor, a receptor commonly thought to modulate neuroleptic activity. Agranulocytosis is a major adverse effect associated with administration of this agent. Clozaril,Leponex
D006760 Hospitalization The confinement of a patient in a hospital. Hospitalizations
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D012189 Retrospective Studies Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons. Retrospective Study,Studies, Retrospective,Study, Retrospective
D012559 Schizophrenia A severe emotional disorder of psychotic depth characteristically marked by a retreat from reality with delusion formation, HALLUCINATIONS, emotional disharmony, and regressive behavior. Dementia Praecox,Schizophrenic Disorders,Disorder, Schizophrenic,Disorders, Schizophrenic,Schizophrenias,Schizophrenic Disorder
D012565 Schizophrenic Psychology Study of mental processes and behavior of schizophrenics. Psychology, Schizophrenic
D012934 Social Isolation The separation of individuals or groups resulting in the lack of or minimizing of social contact and/or communication. This separation may be accomplished by physical separation, by social barriers and by psychological mechanisms. In the latter, there may be interaction but no real communication. Isolation, Social,Social Exclusion,Exclusion, Social,Social Exclusions

Related Publications

A R Mallya, and P D Roos, and K Roebuck-Colgan
Seclusion & restraint.
April 1990, Journal of psychosocial nursing and mental health services,
A R Mallya, and P D Roos, and K Roebuck-Colgan
Seclusion and restraint.
January 2001, Journal of child and adolescent psychiatric nursing : official publication of the Association of Child and Adolescent Psychiatric Nurses, Inc,
A R Mallya, and P D Roos, and K Roebuck-Colgan
Effects of clozapine on use of seclusion and restraint at a state hospital.
March 1994, Hospital & community psychiatry,
A R Mallya, and P D Roos, and K Roebuck-Colgan
Restraint and seclusion record.
October 1994, Journal of emergency nursing,
A R Mallya, and P D Roos, and K Roebuck-Colgan
More on seclusion and restraint.
January 2001, Perspectives in psychiatric care,
A R Mallya, and P D Roos, and K Roebuck-Colgan
Medicaid restraint and seclusion rule.
October 2001, The Kansas nurse,
A R Mallya, and P D Roos, and K Roebuck-Colgan
Restraint and seclusion: progress update.
January 1999, Joint Commission perspectives. Joint Commission on Accreditation of Healthcare Organizations,
A R Mallya, and P D Roos, and K Roebuck-Colgan
Re.: Seclusion, restraint, and restraint reduction (APNA, 2014).
January 2014, Journal of the American Psychiatric Nurses Association,
A R Mallya, and P D Roos, and K Roebuck-Colgan
More on Seclusion & Restraint.
January 2005, Journal of psychosocial nursing and mental health services,
A R Mallya, and P D Roos, and K Roebuck-Colgan
More on seclusion & restraint.
January 2005, Journal of psychosocial nursing and mental health services,
Copied contents to your clipboard!