BIOMAT Database Logo BIOMAT Database Logo

Preparation of Holmium-166 Labelled Macroaggregates for radionuclide synovectomy. 2003

Martin Kropácek, and Frantisek Melichar, and Katerina Henková, and Marie Konopková
Nuclear Physics Institute, Czech Academy of Science, Rez, Czech Republic. kropacek@ujf.cas.cz

BACKGROUND Radionuclide synovectomy (radiation synovectomy) is an alternative method that cures patients with rheumatoid arthritis diseases without surgery. During treatment, the suspension of the (166)Ho-macroaggregates radioactive particles ((166)Ho-MA) is administrated via intra-articular injection into the target joint to destroy the inflamed synovium. METHODS The isotope of (166)Ho (E(beta) max = 1.84 MeV, T((1/2)) = 26.8 hr) was prepared by the (165)Ho(n, gamma)(166)Ho reaction in the LWR-15 nuclear reactor (8-10 MW) using approximate neutron flux 10(14) cm-2s-1. RESULTS The particles of Ho-Macroaggregates with suitable dimension 1-20 microm and the mean diameter of 8.5 microm were prepared. High in-vitro stability was obtained after incubation of neutron-irradiated Ho-Macroaggregates in saline solution (0.9% NaCl). The in-vivo stability on rats was verified as well. CONCLUSIONS High in-vivo and in-vitro stability as well as supporting gamma radiation of Ho-166 make the Macroaggregates a prospective agent for radionuclide synovectomy. The method of preparation is relatively easy and allows for the production of particles of a suitable dimension with a sufficient amount of radioactivity of Ho-166 for the treatment of the rheumatoid arthritis.

UI MeSH Term Description Entries
D007270 Injections, Intra-Articular Methods of delivering drugs into a joint space. Intra Articular Injection,Intraarticular Injection,Injections, Intraarticular,Intra-Articular Injections,Intraarticular Injections,Articular Injection, Intra,Articular Injections, Intra,Injection, Intra Articular,Injection, Intra-Articular,Injection, Intraarticular,Injections, Intra Articular,Intra Articular Injections,Intra-Articular Injection
D007553 Isotope Labeling Techniques for labeling a substance with a stable or radioactive isotope. It is not used for articles involving labeled substances unless the methods of labeling are substantively discussed. Tracers that may be labeled include chemical substances, cells, or microorganisms. Isotope Labeling, Stable,Isotope-Coded Affinity Tagging,Isotopically-Coded Affinity Tagging,Affinity Tagging, Isotope-Coded,Affinity Tagging, Isotopically-Coded,Isotope Coded Affinity Tagging,Labeling, Isotope,Labeling, Stable Isotope,Stable Isotope Labeling,Tagging, Isotope-Coded Affinity,Tagging, Isotopically-Coded Affinity
D007719 Knee Joint A synovial hinge connection formed between the bones of the FEMUR; TIBIA; and PATELLA. Superior Tibiofibular Joint,Joint, Knee,Joint, Superior Tibiofibular,Knee Joints,Superior Tibiofibular Joints,Tibiofibular Joint, Superior
D009928 Organ Specificity Characteristic restricted to a particular organ of the body, such as a cell type, metabolic response or expression of a particular protein or antigen. Tissue Specificity,Organ Specificities,Specificities, Organ,Specificities, Tissue,Specificity, Organ,Specificity, Tissue,Tissue Specificities
D011868 Radioisotopes Isotopes that exhibit radioactivity and undergo radioactive decay. (From Grant & Hackh's Chemical Dictionary, 5th ed & McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed) Daughter Isotope,Daughter Nuclide,Radioactive Isotope,Radioactive Isotopes,Radiogenic Isotope,Radioisotope,Radionuclide,Radionuclides,Daughter Nuclides,Daugter Isotopes,Radiogenic Isotopes,Isotope, Daughter,Isotope, Radioactive,Isotope, Radiogenic,Isotopes, Daugter,Isotopes, Radioactive,Isotopes, Radiogenic,Nuclide, Daughter,Nuclides, Daughter
D011877 Radionuclide Imaging The production of an image obtained by cameras that detect the radioactive emissions of an injected radionuclide as it has distributed differentially throughout tissues in the body. The image obtained from a moving detector is called a scan, while the image obtained from a stationary camera device is called a scintiphotograph. Gamma Camera Imaging,Radioisotope Scanning,Scanning, Radioisotope,Scintigraphy,Scintiphotography,Imaging, Gamma Camera,Imaging, Radionuclide
D004353 Drug Evaluation, Preclinical Preclinical testing of drugs in experimental animals or in vitro for their biological and toxic effects and potential clinical applications. Drug Screening,Evaluation Studies, Drug, Pre-Clinical,Drug Evaluation Studies, Preclinical,Drug Evaluations, Preclinical,Evaluation Studies, Drug, Preclinical,Evaluation, Preclinical Drug,Evaluations, Preclinical Drug,Medicinal Plants Testing, Preclinical,Preclinical Drug Evaluation,Preclinical Drug Evaluations,Drug Screenings,Screening, Drug,Screenings, Drug
D004355 Drug Stability The chemical and physical integrity of a pharmaceutical product. Drug Shelf Life,Drugs Shelf Lives,Shelf Life, Drugs,Drug Stabilities,Drugs Shelf Life,Drugs Shelf Live,Life, Drugs Shelf,Shelf Life, Drug,Shelf Live, Drugs,Shelf Lives, Drugs
D006695 Holmium An element of the rare earth family of metals. It has the atomic symbol Ho, atomic number 67, and atomic weight 164.93.
D006863 Hydrogen-Ion Concentration The normality of a solution with respect to HYDROGEN ions; H+. It is related to acidity measurements in most cases by pH pH,Concentration, Hydrogen-Ion,Concentrations, Hydrogen-Ion,Hydrogen Ion Concentration,Hydrogen-Ion Concentrations

Related Publications

Martin Kropácek, and Frantisek Melichar, and Katerina Henková, and Marie Konopková
Polymeric microspheres for radionuclide synovectomy containing neutron-activated holmium-166.
March 1992, Journal of nuclear medicine : official publication, Society of Nuclear Medicine,
Martin Kropácek, and Frantisek Melichar, and Katerina Henková, and Marie Konopková
Preparation and characterization of inorganic radioactive holmium-166 microspheres for internal radionuclide therapy.
January 2020, Materials science & engineering. C, Materials for biological applications,
Martin Kropácek, and Frantisek Melichar, and Katerina Henková, and Marie Konopková
Our first clinical experience with radiosynoviorthesis by means of (166)Ho-holmium-boro-macroaggregates.
January 2005, Nuclear medicine review. Central & Eastern Europe,
Martin Kropácek, and Frantisek Melichar, and Katerina Henková, and Marie Konopková
Experimental radiation synovectomy in rabbit knee with holmium-166 ferric hydroxide macroaggregate.
July 2002, Nuclear medicine and biology,
Martin Kropácek, and Frantisek Melichar, and Katerina Henková, and Marie Konopková
Radiation synovectomy with holmium-166 ferric hydroxide macroaggregate in equine metacarpophalangeal and metatarsophalangeal joints.
January 2003, Veterinary surgery : VS,
Martin Kropácek, and Frantisek Melichar, and Katerina Henková, and Marie Konopková
Dysprosium-165 ferric hydroxide macroaggregates for radiation synovectomy.
March 1978, Journal of nuclear medicine : official publication, Society of Nuclear Medicine,
Martin Kropácek, and Frantisek Melichar, and Katerina Henková, and Marie Konopková
Holmium-166 poly lactic acid microspheres applicable for intra-arterial radionuclide therapy of hepatic malignancies: effects of preparation and neutron activation techniques.
July 1999, European journal of nuclear medicine,
Martin Kropácek, and Frantisek Melichar, and Katerina Henková, and Marie Konopková
Percutaneous sclerotherapy of renal cysts with a beta-emitting radionuclide, holmium-166-chitosan complex.
January 2004, Korean journal of radiology,
Martin Kropácek, and Frantisek Melichar, and Katerina Henková, and Marie Konopková
Dysprosium (165Dy) hydroxide macroaggregates for radiation synovectomy--animal studies.
January 1990, European journal of nuclear medicine,
Martin Kropácek, and Frantisek Melichar, and Katerina Henková, and Marie Konopková
Radiolabeling antibodies with holmium-166.
April 1997, Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine,
Copied contents to your clipboard!