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Carbocyclic isoadenosine analogues of neplanocin A. 2003

Katherine L Seley, and Sylvester L Mosley, and Fanxing Zeng
School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, Georgia, USA. kseley@umbc.edu

[structure: see text] Isoadenosine (IsoA), a structural isomer of adenosine, was shown to possess interesting biological activity but was inherently unstable. In an effort to overcome this, we have designed a series of carbocyclic IsoA analogues, combining the unique connectivity of IsoA with the structural features of some biologically significant Neplanocin A analogues. Their design, synthesis, and structural elucidation is reported.

UI MeSH Term Description Entries
D000241 Adenosine A nucleoside that is composed of ADENINE and D-RIBOSE. Adenosine or adenosine derivatives play many important biological roles in addition to being components of DNA and RNA. Adenosine itself is a neurotransmitter. Adenocard,Adenoscan

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