Biomaterial Database

Staging and classification of gestational trophoblastic disease. 2003

Barry William Hancock

Trophoblastic Disease Unit Weston Park Hospital, Whitham Road, S10 2JS Sheffield, UK. b.w.hancock@sheffield.ac.uk

Many staging, classification and prognostic systems have been applied to persistent trophoblastic disease. Also terminology has differed across the world, together with criteria for treatment. Consequently it has been difficult to compare results from different centres and it is likely that some patients have been either under or over treated, resulting in increased chemoresistance or treatment toxicity, respectively. There is a need for globally agreed guidelines. This chapter addresses developments leading up to the recent publication of an internationally agreed staging/prognostic scoring system.

UI	MeSH Term	Description	Entries
D009367	Neoplasm Staging	Methods which attempt to express in replicable terms the extent of the neoplasm in the patient.	Cancer Staging,Staging, Neoplasm,Tumor Staging,TNM Classification,TNM Staging,TNM Staging System,Classification, TNM,Classifications, TNM,Staging System, TNM,Staging Systems, TNM,Staging, Cancer,Staging, TNM,Staging, Tumor,System, TNM Staging,Systems, TNM Staging,TNM Classifications,TNM Staging Systems
D011247	Pregnancy	The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.	Gestation,Pregnancies
D011379	Prognosis	A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations.	Prognostic Factor,Prognostic Factors,Factor, Prognostic,Factors, Prognostic,Prognoses
D005260	Female		Females
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D012307	Risk Factors	An aspect of personal behavior or lifestyle, environmental exposure, inborn or inherited characteristic, which, based on epidemiological evidence, is known to be associated with a health-related condition considered important to prevent.	Health Correlates,Risk Factor Scores,Risk Scores,Social Risk Factors,Population at Risk,Populations at Risk,Correlates, Health,Factor, Risk,Factor, Social Risk,Factors, Social Risk,Risk Factor,Risk Factor Score,Risk Factor, Social,Risk Factors, Social,Risk Score,Score, Risk,Score, Risk Factor,Social Risk Factor
D012720	Severity of Illness Index	Levels within a diagnostic group which are established by various measurement criteria applied to the seriousness of a patient's disorder.	Illness Index Severities,Illness Index Severity
D015999	Multivariate Analysis	A set of techniques used when variation in several variables are studied simultaneously. In statistics, multivariate analysis is interpreted as any analytic method that allows simultaneous study of two or more dependent variables.	Analysis, Multivariate,Multivariate Analyses
D017410	Practice Guidelines as Topic	Works about directions or principles presenting current or future rules of policy for assisting health care practitioners in patient care decisions regarding diagnosis, therapy, or related clinical circumstances. The guidelines may be developed by government agencies at any level, institutions, professional societies, governing boards, or by the convening of expert panels. The guidelines form a basis for the evaluation of all aspects of health care and delivery.	Clinical Guidelines as Topic,Best Practices,Best Practice
D031901	Gestational Trophoblastic Disease	A group of diseases arising from pregnancy that are commonly associated with hyperplasia of trophoblasts (TROPHOBLAST) and markedly elevated human CHORIONIC GONADOTROPIN. They include HYDATIDIFORM MOLE, invasive mole (HYDATIDIFORM MOLE, INVASIVE), placental-site trophoblastic tumor (TROPHOBLASTIC TUMOR, PLACENTAL SITE), and CHORIOCARCINOMA. These neoplasms have varying propensities for invasion and spread.	Gestational Trophoblastic Neoplasms,Trophoblastic Neoplasms, Gestational,Gestational Trophoblastic Neoplasia,Disease, Gestational Trophoblastic,Diseases, Gestational Trophoblastic,Gestational Trophoblastic Diseases,Gestational Trophoblastic Neoplasm,Neoplasia, Gestational Trophoblastic,Neoplasm, Gestational Trophoblastic,Neoplasms, Gestational Trophoblastic,Trophoblastic Disease, Gestational,Trophoblastic Diseases, Gestational,Trophoblastic Neoplasia, Gestational,Trophoblastic Neoplasm, Gestational