OBJECTIVE To study clinical features of skeletal tuberculosis diagnosed in our laboratory over the last 10 years. METHODS We carried out a retrospective observational study of 26 patients with osteoarticular tuberculosis recording clinical and microbiological data. RESULTS Pain was the main clinical presentation. The median time from the onset of symptoms to the diagnosis was 8 months. Synovial fluid was the most common sample obtained. Bone disease and previous or concurrent pulmonary tuberculosis were the most important predisposing factors. The tuberculin test reaction was positive in 83.3% of the patients. The outcome was favorable in 69% of the patients. Weight-bearing joints were the most commonly involved sites. CONCLUSIONS A high degree of suspicion is still needed to avoid a delayed diagnosis that might complicate the outcome.