-transparent.png){kind=logo}
This study describes an animal model for delirium comparing rats treated with either saline or atropine. The model was defined by recordings of cortical EEGs, maze performance, and behavioral observations. EEG slowing and increased amplitude, difficulty with attention and memory, sleep-wake cycle reversal, and changes in behavior (lack of focused direction, irritability, fluctuating levels of activity, excessive random sniffing) appeared consistent with signs and symptoms seen in human delirium. EEG abnormalities in atropine-treated rats returned to normal before cognitive deficits did. Motor activity monitoring did not reveal diminished motor activity as a confounding variable in maze performance.
P T Trzepacz, and
M Leavitt, and
K Ciongoli
August 2019,
Studies in health technology and informatics,
P T Trzepacz, and
M Leavitt, and
K Ciongoli
November 2017,
BMJ open,
P T Trzepacz, and
M Leavitt, and
K Ciongoli
March 1988,
The Laryngoscope,
P T Trzepacz, and
M Leavitt, and
K Ciongoli
November 1972,
The Laryngoscope,
P T Trzepacz, and
M Leavitt, and
K Ciongoli
October 1996,
Seminars in clinical neuropsychiatry,
P T Trzepacz, and
M Leavitt, and
K Ciongoli
February 1977,
Surgery,
P T Trzepacz, and
M Leavitt, and
K Ciongoli
February 1982,
The British journal of dermatology,
P T Trzepacz, and
M Leavitt, and
K Ciongoli
January 1988,
Annals of the New York Academy of Sciences,
P T Trzepacz, and
M Leavitt, and
K Ciongoli
October 1972,
Gut,
